Cargando…

Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy

PURPOSE: Postoperative pancreatic fistula is a serious complication of distal pancreatectomy. Although many studies have described the incidence and risk factors associated with postoperative pancreatic fistula (POPF), few have focused on the healing time. This study investigated the healing time an...

Descripción completa

Detalles Bibliográficos
Autores principales: Toya, Keisuke, Tomimaru, Yoshito, Kobayashi, Shogo, Sasaki, Kazuki, Iwagami, Yoshifumi, Yamada, Daisaku, Noda, Takehiro, Takahashi, Hidenori, Doki, Yuichiro, Eguchi, Hidetoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786688/
https://www.ncbi.nlm.nih.gov/pubmed/35106427
http://dx.doi.org/10.1002/ags3.12510
_version_ 1784639169585217536
author Toya, Keisuke
Tomimaru, Yoshito
Kobayashi, Shogo
Sasaki, Kazuki
Iwagami, Yoshifumi
Yamada, Daisaku
Noda, Takehiro
Takahashi, Hidenori
Doki, Yuichiro
Eguchi, Hidetoshi
author_facet Toya, Keisuke
Tomimaru, Yoshito
Kobayashi, Shogo
Sasaki, Kazuki
Iwagami, Yoshifumi
Yamada, Daisaku
Noda, Takehiro
Takahashi, Hidenori
Doki, Yuichiro
Eguchi, Hidetoshi
author_sort Toya, Keisuke
collection PubMed
description PURPOSE: Postoperative pancreatic fistula is a serious complication of distal pancreatectomy. Although many studies have described the incidence and risk factors associated with postoperative pancreatic fistula (POPF), few have focused on the healing time. This study investigated the healing time and potential factors associated with the healing time of POPF after distal pancreatectomy (DP). METHODS: Among 114 patients that underwent DP in our hospital from January 2010 to December 2020, we included 88 that developed POPF. The healing time for a postoperative pancreatic fistula was defined as the interval between the completion of DP and the removal of all drains related to the treatment for POPF. Based on the definition, three cases who required additional treatment after removal of all drains were excluded from this study. Clinical factors associated with the fistula healing times were investigated in the 85 patients. RESULTS: The average POPF healing time was 11 ± 10 days (median: 6 days, range: 3‐57). We found that the neutrophil‐to‐lymphocyte ratio, a marker of inflammatory and nutritional status, was the only factor independently associated with the POPF healing time; the mean healing time was significantly shorter in patients with neutrophil‐to‐lymphocyte ratio ≤2.1 (8 ± 6 days) than in those with neutrophil‐to‐lymphocyte ratio >2.1 (13 ± 12 days; P = .0139). CONCLUSION: We demonstrated that the neutrophil‐to‐lymphocyte ratio could independently predict the POPF healing time after DP. These findings suggested that improving the neutrophil‐to‐lymphocyte ratio might shorten the healing times for POPF after DP.
format Online
Article
Text
id pubmed-8786688
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-87866882022-01-31 Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy Toya, Keisuke Tomimaru, Yoshito Kobayashi, Shogo Sasaki, Kazuki Iwagami, Yoshifumi Yamada, Daisaku Noda, Takehiro Takahashi, Hidenori Doki, Yuichiro Eguchi, Hidetoshi Ann Gastroenterol Surg Original Articles PURPOSE: Postoperative pancreatic fistula is a serious complication of distal pancreatectomy. Although many studies have described the incidence and risk factors associated with postoperative pancreatic fistula (POPF), few have focused on the healing time. This study investigated the healing time and potential factors associated with the healing time of POPF after distal pancreatectomy (DP). METHODS: Among 114 patients that underwent DP in our hospital from January 2010 to December 2020, we included 88 that developed POPF. The healing time for a postoperative pancreatic fistula was defined as the interval between the completion of DP and the removal of all drains related to the treatment for POPF. Based on the definition, three cases who required additional treatment after removal of all drains were excluded from this study. Clinical factors associated with the fistula healing times were investigated in the 85 patients. RESULTS: The average POPF healing time was 11 ± 10 days (median: 6 days, range: 3‐57). We found that the neutrophil‐to‐lymphocyte ratio, a marker of inflammatory and nutritional status, was the only factor independently associated with the POPF healing time; the mean healing time was significantly shorter in patients with neutrophil‐to‐lymphocyte ratio ≤2.1 (8 ± 6 days) than in those with neutrophil‐to‐lymphocyte ratio >2.1 (13 ± 12 days; P = .0139). CONCLUSION: We demonstrated that the neutrophil‐to‐lymphocyte ratio could independently predict the POPF healing time after DP. These findings suggested that improving the neutrophil‐to‐lymphocyte ratio might shorten the healing times for POPF after DP. John Wiley and Sons Inc. 2021-10-04 /pmc/articles/PMC8786688/ /pubmed/35106427 http://dx.doi.org/10.1002/ags3.12510 Text en © 2021 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Toya, Keisuke
Tomimaru, Yoshito
Kobayashi, Shogo
Sasaki, Kazuki
Iwagami, Yoshifumi
Yamada, Daisaku
Noda, Takehiro
Takahashi, Hidenori
Doki, Yuichiro
Eguchi, Hidetoshi
Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
title Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
title_full Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
title_fullStr Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
title_full_unstemmed Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
title_short Preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
title_sort preoperative neutrophil‐to‐lymphocyte ratio predicts healing time for postoperative pancreatic fistula after distal pancreatectomy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786688/
https://www.ncbi.nlm.nih.gov/pubmed/35106427
http://dx.doi.org/10.1002/ags3.12510
work_keys_str_mv AT toyakeisuke preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT tomimaruyoshito preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT kobayashishogo preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT sasakikazuki preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT iwagamiyoshifumi preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT yamadadaisaku preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT nodatakehiro preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT takahashihidenori preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT dokiyuichiro preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy
AT eguchihidetoshi preoperativeneutrophiltolymphocyteratiopredictshealingtimeforpostoperativepancreaticfistulaafterdistalpancreatectomy