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Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study

AIM: The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. METHODS: To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. RESULTS:...

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Autores principales: Imaoka, Yuki, Ohira, Masahiro, Sato, Koki, Imaoka, Kouki, Kuroda, Shintaro, Tahara, Hiroyuki, Kobayashi, Tsuyoshi, Ide, Kentaro, Tanaka, Yuka, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786692/
https://www.ncbi.nlm.nih.gov/pubmed/35106425
http://dx.doi.org/10.1002/ags3.12508
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author Imaoka, Yuki
Ohira, Masahiro
Sato, Koki
Imaoka, Kouki
Kuroda, Shintaro
Tahara, Hiroyuki
Kobayashi, Tsuyoshi
Ide, Kentaro
Tanaka, Yuka
Ohdan, Hideki
author_facet Imaoka, Yuki
Ohira, Masahiro
Sato, Koki
Imaoka, Kouki
Kuroda, Shintaro
Tahara, Hiroyuki
Kobayashi, Tsuyoshi
Ide, Kentaro
Tanaka, Yuka
Ohdan, Hideki
author_sort Imaoka, Yuki
collection PubMed
description AIM: The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. METHODS: To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. RESULTS: Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). CONCLUSIONS: Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score.
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spelling pubmed-87866922022-01-31 Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study Imaoka, Yuki Ohira, Masahiro Sato, Koki Imaoka, Kouki Kuroda, Shintaro Tahara, Hiroyuki Kobayashi, Tsuyoshi Ide, Kentaro Tanaka, Yuka Ohdan, Hideki Ann Gastroenterol Surg Original Articles AIM: The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. METHODS: To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. RESULTS: Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). CONCLUSIONS: Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score. John Wiley and Sons Inc. 2021-09-19 /pmc/articles/PMC8786692/ /pubmed/35106425 http://dx.doi.org/10.1002/ags3.12508 Text en © 2021 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Imaoka, Yuki
Ohira, Masahiro
Sato, Koki
Imaoka, Kouki
Kuroda, Shintaro
Tahara, Hiroyuki
Kobayashi, Tsuyoshi
Ide, Kentaro
Tanaka, Yuka
Ohdan, Hideki
Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
title Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
title_full Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
title_fullStr Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
title_full_unstemmed Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
title_short Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study
title_sort impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: a retrospective cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786692/
https://www.ncbi.nlm.nih.gov/pubmed/35106425
http://dx.doi.org/10.1002/ags3.12508
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