Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesi...

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Autores principales: Su, Xuan, Yue, Peng, Kong, Jing, Xu, Xin, Zhang, Yu, Cao, Wenjing, Fan, Yuxin, Liu, Meixiao, Chen, Jingjing, Liu, Aihua, Bao, Fukai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786735/
https://www.ncbi.nlm.nih.gov/pubmed/35087520
http://dx.doi.org/10.3389/fimmu.2021.792316
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author Su, Xuan
Yue, Peng
Kong, Jing
Xu, Xin
Zhang, Yu
Cao, Wenjing
Fan, Yuxin
Liu, Meixiao
Chen, Jingjing
Liu, Aihua
Bao, Fukai
author_facet Su, Xuan
Yue, Peng
Kong, Jing
Xu, Xin
Zhang, Yu
Cao, Wenjing
Fan, Yuxin
Liu, Meixiao
Chen, Jingjing
Liu, Aihua
Bao, Fukai
author_sort Su, Xuan
collection PubMed
description Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesis of SARS-CoV-2, human immunodeficiency virus (HIV), HSV-1, and other viral infections of the CNS. In this review, we summarize the advances in the development of viral infection models in brain organoids and their potential application for exploring mechanisms of viral infections of the CNS and in new drug development. The existing limitations are further discussed and the prospects for the development and application of brain organs are prospected.
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spelling pubmed-87867352022-01-26 Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases Su, Xuan Yue, Peng Kong, Jing Xu, Xin Zhang, Yu Cao, Wenjing Fan, Yuxin Liu, Meixiao Chen, Jingjing Liu, Aihua Bao, Fukai Front Immunol Immunology Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesis of SARS-CoV-2, human immunodeficiency virus (HIV), HSV-1, and other viral infections of the CNS. In this review, we summarize the advances in the development of viral infection models in brain organoids and their potential application for exploring mechanisms of viral infections of the CNS and in new drug development. The existing limitations are further discussed and the prospects for the development and application of brain organs are prospected. Frontiers Media S.A. 2022-01-11 /pmc/articles/PMC8786735/ /pubmed/35087520 http://dx.doi.org/10.3389/fimmu.2021.792316 Text en Copyright © 2022 Su, Yue, Kong, Xu, Zhang, Cao, Fan, Liu, Chen, Liu and Bao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Su, Xuan
Yue, Peng
Kong, Jing
Xu, Xin
Zhang, Yu
Cao, Wenjing
Fan, Yuxin
Liu, Meixiao
Chen, Jingjing
Liu, Aihua
Bao, Fukai
Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
title Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
title_full Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
title_fullStr Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
title_full_unstemmed Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
title_short Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
title_sort human brain organoids as an in vitro model system of viral infectious diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786735/
https://www.ncbi.nlm.nih.gov/pubmed/35087520
http://dx.doi.org/10.3389/fimmu.2021.792316
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