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Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
PURPOSE: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessme...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786756/ https://www.ncbi.nlm.nih.gov/pubmed/34529133 http://dx.doi.org/10.1007/s00417-021-05334-6 |
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author | Ademmer, Vanessa Agha, Bishr Shajari, Mehdi Kohnen, Thomas Schmack, Ingo |
author_facet | Ademmer, Vanessa Agha, Bishr Shajari, Mehdi Kohnen, Thomas Schmack, Ingo |
author_sort | Ademmer, Vanessa |
collection | PubMed |
description | PURPOSE: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessment included the Quality of Vision (QoV) questionnaire preoperatively, at 1 month, and 3 months after surgery. Secondary outcome measures were anterior segment parameters acquired by Scheimpflug imaging, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). RESULTS: Glare, hazy vision, blurred vision, and daily fluctuation in vision were the symptoms mostly reported preoperatively. All symptoms demonstrated a significant reduction of item scores for severity, frequency, and bothersome in the course after DMEK (P < 0.01). Glare and fluctuation in vision remained to some extent during the follow-up period (median score = 1). Preoperatively, corneal densitometry correlated moderately to weakly with severity of hazy vision (r(s) = 0.39; P = 0.03) and frequency (r(s) = 0.26; P = 0.02) as well as severity (r(s) = 0.27; P = 0.03) of blurry vision. CDVA and central corneal thickness (CCT) did not correlate with visual complains. CONCLUSIONS: Following DMEK for FED, patient-reported visual symptoms assessed by the QoV questionnaire represent a useful tool providing valuable information on the impact of DMEK on visual quality that cannot be directly estimated by morphological parameters and visual acuity only. |
format | Online Article Text |
id | pubmed-8786756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-87867562022-02-02 Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy Ademmer, Vanessa Agha, Bishr Shajari, Mehdi Kohnen, Thomas Schmack, Ingo Graefes Arch Clin Exp Ophthalmol Cornea PURPOSE: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessment included the Quality of Vision (QoV) questionnaire preoperatively, at 1 month, and 3 months after surgery. Secondary outcome measures were anterior segment parameters acquired by Scheimpflug imaging, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). RESULTS: Glare, hazy vision, blurred vision, and daily fluctuation in vision were the symptoms mostly reported preoperatively. All symptoms demonstrated a significant reduction of item scores for severity, frequency, and bothersome in the course after DMEK (P < 0.01). Glare and fluctuation in vision remained to some extent during the follow-up period (median score = 1). Preoperatively, corneal densitometry correlated moderately to weakly with severity of hazy vision (r(s) = 0.39; P = 0.03) and frequency (r(s) = 0.26; P = 0.02) as well as severity (r(s) = 0.27; P = 0.03) of blurry vision. CDVA and central corneal thickness (CCT) did not correlate with visual complains. CONCLUSIONS: Following DMEK for FED, patient-reported visual symptoms assessed by the QoV questionnaire represent a useful tool providing valuable information on the impact of DMEK on visual quality that cannot be directly estimated by morphological parameters and visual acuity only. Springer Berlin Heidelberg 2021-09-16 2022 /pmc/articles/PMC8786756/ /pubmed/34529133 http://dx.doi.org/10.1007/s00417-021-05334-6 Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cornea Ademmer, Vanessa Agha, Bishr Shajari, Mehdi Kohnen, Thomas Schmack, Ingo Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy |
title | Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy |
title_full | Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy |
title_fullStr | Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy |
title_full_unstemmed | Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy |
title_short | Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy |
title_sort | impact of dmek on visual quality in patients with fuchs’ endothelial dystrophy |
topic | Cornea |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786756/ https://www.ncbi.nlm.nih.gov/pubmed/34529133 http://dx.doi.org/10.1007/s00417-021-05334-6 |
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