Cargando…

Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy

PURPOSE: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessme...

Descripción completa

Detalles Bibliográficos
Autores principales: Ademmer, Vanessa, Agha, Bishr, Shajari, Mehdi, Kohnen, Thomas, Schmack, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786756/
https://www.ncbi.nlm.nih.gov/pubmed/34529133
http://dx.doi.org/10.1007/s00417-021-05334-6
_version_ 1784639186601508864
author Ademmer, Vanessa
Agha, Bishr
Shajari, Mehdi
Kohnen, Thomas
Schmack, Ingo
author_facet Ademmer, Vanessa
Agha, Bishr
Shajari, Mehdi
Kohnen, Thomas
Schmack, Ingo
author_sort Ademmer, Vanessa
collection PubMed
description PURPOSE: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessment included the Quality of Vision (QoV) questionnaire preoperatively, at 1 month, and 3 months after surgery. Secondary outcome measures were anterior segment parameters acquired by Scheimpflug imaging, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). RESULTS: Glare, hazy vision, blurred vision, and daily fluctuation in vision were the symptoms mostly reported preoperatively. All symptoms demonstrated a significant reduction of item scores for severity, frequency, and bothersome in the course after DMEK (P < 0.01). Glare and fluctuation in vision remained to some extent during the follow-up period (median score = 1). Preoperatively, corneal densitometry correlated moderately to weakly with severity of hazy vision (r(s) = 0.39; P = 0.03) and frequency (r(s) = 0.26; P = 0.02) as well as severity (r(s) = 0.27; P = 0.03) of blurry vision. CDVA and central corneal thickness (CCT) did not correlate with visual complains. CONCLUSIONS: Following DMEK for FED, patient-reported visual symptoms assessed by the QoV questionnaire represent a useful tool providing valuable information on the impact of DMEK on visual quality that cannot be directly estimated by morphological parameters and visual acuity only.
format Online
Article
Text
id pubmed-8786756
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-87867562022-02-02 Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy Ademmer, Vanessa Agha, Bishr Shajari, Mehdi Kohnen, Thomas Schmack, Ingo Graefes Arch Clin Exp Ophthalmol Cornea PURPOSE: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). METHODS: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessment included the Quality of Vision (QoV) questionnaire preoperatively, at 1 month, and 3 months after surgery. Secondary outcome measures were anterior segment parameters acquired by Scheimpflug imaging, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). RESULTS: Glare, hazy vision, blurred vision, and daily fluctuation in vision were the symptoms mostly reported preoperatively. All symptoms demonstrated a significant reduction of item scores for severity, frequency, and bothersome in the course after DMEK (P < 0.01). Glare and fluctuation in vision remained to some extent during the follow-up period (median score = 1). Preoperatively, corneal densitometry correlated moderately to weakly with severity of hazy vision (r(s) = 0.39; P = 0.03) and frequency (r(s) = 0.26; P = 0.02) as well as severity (r(s) = 0.27; P = 0.03) of blurry vision. CDVA and central corneal thickness (CCT) did not correlate with visual complains. CONCLUSIONS: Following DMEK for FED, patient-reported visual symptoms assessed by the QoV questionnaire represent a useful tool providing valuable information on the impact of DMEK on visual quality that cannot be directly estimated by morphological parameters and visual acuity only. Springer Berlin Heidelberg 2021-09-16 2022 /pmc/articles/PMC8786756/ /pubmed/34529133 http://dx.doi.org/10.1007/s00417-021-05334-6 Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cornea
Ademmer, Vanessa
Agha, Bishr
Shajari, Mehdi
Kohnen, Thomas
Schmack, Ingo
Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
title Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
title_full Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
title_fullStr Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
title_full_unstemmed Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
title_short Impact of DMEK on visual quality in patients with Fuchs’ endothelial dystrophy
title_sort impact of dmek on visual quality in patients with fuchs’ endothelial dystrophy
topic Cornea
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786756/
https://www.ncbi.nlm.nih.gov/pubmed/34529133
http://dx.doi.org/10.1007/s00417-021-05334-6
work_keys_str_mv AT ademmervanessa impactofdmekonvisualqualityinpatientswithfuchsendothelialdystrophy
AT aghabishr impactofdmekonvisualqualityinpatientswithfuchsendothelialdystrophy
AT shajarimehdi impactofdmekonvisualqualityinpatientswithfuchsendothelialdystrophy
AT kohnenthomas impactofdmekonvisualqualityinpatientswithfuchsendothelialdystrophy
AT schmackingo impactofdmekonvisualqualityinpatientswithfuchsendothelialdystrophy