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MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered physiological and pathological effects are regulated at the rec...

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Detalles Bibliográficos
Autores principales:	Feng, Lu, Li, Chen, Zeng, Lin-Wen, Gao, Deng, Sun, Yu-Hao, Zhong, Li, Lin, Heng, Shu, Hong-Bing, Li, Shu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786845/ https://www.ncbi.nlm.nih.gov/pubmed/35075102 http://dx.doi.org/10.1038/s41392-021-00834-7

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