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Oxygen transport during liquid ventilation: an in vitro study
An in vitro experiment on the dissolved oxygen transport during liquid ventilation by means of measuring global oxygen concentration fields is presented within this work. We consider the flow in an idealized four generation model of the human airways in a range of peak Reynolds numbers of [Formula:...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786849/ https://www.ncbi.nlm.nih.gov/pubmed/35075158 http://dx.doi.org/10.1038/s41598-022-05105-1 |
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author | Bauer, Katrin Janke, Thomas Schwarze, Rüdiger |
author_facet | Bauer, Katrin Janke, Thomas Schwarze, Rüdiger |
author_sort | Bauer, Katrin |
collection | PubMed |
description | An in vitro experiment on the dissolved oxygen transport during liquid ventilation by means of measuring global oxygen concentration fields is presented within this work. We consider the flow in an idealized four generation model of the human airways in a range of peak Reynolds numbers of [Formula: see text] –3400 and Womersley numbers of [Formula: see text] –5. Fluorescence quenching measurements were employed in order to visualize and quantify the oxygen distribution with high temporal and spatial resolution during the breathing cycle. Measurements with varying tidal volumes and oscillating frequencies reveal short living times of characteristic concentration patterns for all parameter variations. Similarities to typical velocity patterns in similar lung models persist only in early phases during each cycle. Concentration gradients are quickly homogenized by secondary motions within the lung model. A strong dependency of peak oxygen concentration on tidal volume is observed with considerably higher relative concentrations for higher tidal volumes. |
format | Online Article Text |
id | pubmed-8786849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87868492022-01-25 Oxygen transport during liquid ventilation: an in vitro study Bauer, Katrin Janke, Thomas Schwarze, Rüdiger Sci Rep Article An in vitro experiment on the dissolved oxygen transport during liquid ventilation by means of measuring global oxygen concentration fields is presented within this work. We consider the flow in an idealized four generation model of the human airways in a range of peak Reynolds numbers of [Formula: see text] –3400 and Womersley numbers of [Formula: see text] –5. Fluorescence quenching measurements were employed in order to visualize and quantify the oxygen distribution with high temporal and spatial resolution during the breathing cycle. Measurements with varying tidal volumes and oscillating frequencies reveal short living times of characteristic concentration patterns for all parameter variations. Similarities to typical velocity patterns in similar lung models persist only in early phases during each cycle. Concentration gradients are quickly homogenized by secondary motions within the lung model. A strong dependency of peak oxygen concentration on tidal volume is observed with considerably higher relative concentrations for higher tidal volumes. Nature Publishing Group UK 2022-01-24 /pmc/articles/PMC8786849/ /pubmed/35075158 http://dx.doi.org/10.1038/s41598-022-05105-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Bauer, Katrin Janke, Thomas Schwarze, Rüdiger Oxygen transport during liquid ventilation: an in vitro study |
title | Oxygen transport during liquid ventilation: an in vitro study |
title_full | Oxygen transport during liquid ventilation: an in vitro study |
title_fullStr | Oxygen transport during liquid ventilation: an in vitro study |
title_full_unstemmed | Oxygen transport during liquid ventilation: an in vitro study |
title_short | Oxygen transport during liquid ventilation: an in vitro study |
title_sort | oxygen transport during liquid ventilation: an in vitro study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786849/ https://www.ncbi.nlm.nih.gov/pubmed/35075158 http://dx.doi.org/10.1038/s41598-022-05105-1 |
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