Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevan...

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Autores principales: Zhou, Xue, Chen, Youdong, Cui, Lian, Shi, Yuling, Guo, Chunyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786887/
https://www.ncbi.nlm.nih.gov/pubmed/35075118
http://dx.doi.org/10.1038/s41419-022-04523-3
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author Zhou, Xue
Chen, Youdong
Cui, Lian
Shi, Yuling
Guo, Chunyuan
author_facet Zhou, Xue
Chen, Youdong
Cui, Lian
Shi, Yuling
Guo, Chunyuan
author_sort Zhou, Xue
collection PubMed
description Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
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spelling pubmed-87868872022-02-07 Advances in the pathogenesis of psoriasis: from keratinocyte perspective Zhou, Xue Chen, Youdong Cui, Lian Shi, Yuling Guo, Chunyuan Cell Death Dis Review Article Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis. Nature Publishing Group UK 2022-01-24 /pmc/articles/PMC8786887/ /pubmed/35075118 http://dx.doi.org/10.1038/s41419-022-04523-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhou, Xue
Chen, Youdong
Cui, Lian
Shi, Yuling
Guo, Chunyuan
Advances in the pathogenesis of psoriasis: from keratinocyte perspective
title Advances in the pathogenesis of psoriasis: from keratinocyte perspective
title_full Advances in the pathogenesis of psoriasis: from keratinocyte perspective
title_fullStr Advances in the pathogenesis of psoriasis: from keratinocyte perspective
title_full_unstemmed Advances in the pathogenesis of psoriasis: from keratinocyte perspective
title_short Advances in the pathogenesis of psoriasis: from keratinocyte perspective
title_sort advances in the pathogenesis of psoriasis: from keratinocyte perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786887/
https://www.ncbi.nlm.nih.gov/pubmed/35075118
http://dx.doi.org/10.1038/s41419-022-04523-3
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