Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain

Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely used to treat chemotherapy-induced nausea and vomiting. In this study, we used LPS-stimulated BV-2 microglia cell line and an...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Zhou, Wei, Xu, Xiuqi, Ge, Xianxiu, Wang, Fei, Zhang, Guang-Qin, Miao, Lin, Deng, Xueting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786910/
https://www.ncbi.nlm.nih.gov/pubmed/35087409
http://dx.doi.org/10.3389/fphar.2021.811584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786910/
https://www.ncbi.nlm.nih.gov/pubmed/35087409
http://dx.doi.org/10.3389/fphar.2021.811584

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