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Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis

Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic agent with rapid hemostasis and excellent antibac...

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Autores principales: Huang, Tingting, Zhou, Zhihao, Li, Qiaoyuan, Tang, Xiaoxuan, Chen, Xiaoli, Ge, Yifan, Ling, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786915/
https://www.ncbi.nlm.nih.gov/pubmed/35087810
http://dx.doi.org/10.3389/fbioe.2021.820434
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author Huang, Tingting
Zhou, Zhihao
Li, Qiaoyuan
Tang, Xiaoxuan
Chen, Xiaoli
Ge, Yifan
Ling, Jue
author_facet Huang, Tingting
Zhou, Zhihao
Li, Qiaoyuan
Tang, Xiaoxuan
Chen, Xiaoli
Ge, Yifan
Ling, Jue
author_sort Huang, Tingting
collection PubMed
description Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic agent with rapid hemostasis and excellent antibacterial activity. In this study, we developed a light responsive hemostatic film for effective handling of liver bleeding with promising photodynamic therapy against S. aureus onnear infrared (NIR) irradiation. Based on silk fibroin, the film exhibited desirable biocompatibility and mechanical property as a hemostat tape. Significantly, the film tape achieved excellent tissue adhesion and hemostasis in vivo within 2 min of UV exposure, which would have a great potential as a multifunctional biomedical material in the field of tissue repair such as wound healing, bone repair, and nerve regeneration.
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spelling pubmed-87869152022-01-26 Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis Huang, Tingting Zhou, Zhihao Li, Qiaoyuan Tang, Xiaoxuan Chen, Xiaoli Ge, Yifan Ling, Jue Front Bioeng Biotechnol Bioengineering and Biotechnology Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic agent with rapid hemostasis and excellent antibacterial activity. In this study, we developed a light responsive hemostatic film for effective handling of liver bleeding with promising photodynamic therapy against S. aureus onnear infrared (NIR) irradiation. Based on silk fibroin, the film exhibited desirable biocompatibility and mechanical property as a hemostat tape. Significantly, the film tape achieved excellent tissue adhesion and hemostasis in vivo within 2 min of UV exposure, which would have a great potential as a multifunctional biomedical material in the field of tissue repair such as wound healing, bone repair, and nerve regeneration. Frontiers Media S.A. 2022-01-11 /pmc/articles/PMC8786915/ /pubmed/35087810 http://dx.doi.org/10.3389/fbioe.2021.820434 Text en Copyright © 2022 Huang, Zhou, Li, Tang, Chen, Ge and Ling. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Huang, Tingting
Zhou, Zhihao
Li, Qiaoyuan
Tang, Xiaoxuan
Chen, Xiaoli
Ge, Yifan
Ling, Jue
Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
title Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
title_full Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
title_fullStr Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
title_full_unstemmed Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
title_short Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis
title_sort light-triggered adhesive silk-based film for effective photodynamic antibacterial therapy and rapid hemostasis
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786915/
https://www.ncbi.nlm.nih.gov/pubmed/35087810
http://dx.doi.org/10.3389/fbioe.2021.820434
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