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Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant
The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequential PCR testing of quarantined individuals indi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786931/ https://www.ncbi.nlm.nih.gov/pubmed/35075154 http://dx.doi.org/10.1038/s41467-022-28089-y |
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| author | Li, Baisheng Deng, Aiping Li, Kuibiao Hu, Yao Li, Zhencui Shi, Yaling Xiong, Qianling Liu, Zhe Guo, Qianfang Zou, Lirong Zhang, Huan Zhang, Meng Ouyang, Fangzhu Su, Juan Su, Wenzhe Xu, Jing Lin, Huifang Sun, Jing Peng, Jinju Jiang, Huiming Zhou, Pingping Hu, Ting Luo, Min Zhang, Yingtao Zheng, Huanying Xiao, Jianpeng Liu, Tao Tan, Mingkai Che, Rongfei Zeng, Hanri Zheng, Zhonghua Huang, Yushi Yu, Jianxiang Yi, Lina Wu, Jie Chen, Jingdiao Zhong, Haojie Deng, Xiaoling Kang, Min Pybus, Oliver G. Hall, Matthew Lythgoe, Katrina A. Li, Yan Yuan, Jun He, Jianfeng Lu, Jing |
| author_facet | Li, Baisheng Deng, Aiping Li, Kuibiao Hu, Yao Li, Zhencui Shi, Yaling Xiong, Qianling Liu, Zhe Guo, Qianfang Zou, Lirong Zhang, Huan Zhang, Meng Ouyang, Fangzhu Su, Juan Su, Wenzhe Xu, Jing Lin, Huifang Sun, Jing Peng, Jinju Jiang, Huiming Zhou, Pingping Hu, Ting Luo, Min Zhang, Yingtao Zheng, Huanying Xiao, Jianpeng Liu, Tao Tan, Mingkai Che, Rongfei Zeng, Hanri Zheng, Zhonghua Huang, Yushi Yu, Jianxiang Yi, Lina Wu, Jie Chen, Jingdiao Zhong, Haojie Deng, Xiaoling Kang, Min Pybus, Oliver G. Hall, Matthew Lythgoe, Katrina A. Li, Yan Yuan, Jun He, Jianfeng Lu, Jing |
| author_sort | Li, Baisheng |
| collection | PubMed |
| description | The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequential PCR testing of quarantined individuals indicated that the viral loads of Delta infections, when they first become PCR-positive, were on average ~1000 times greater compared to lineage A/B infections during the first epidemic wave in China in early 2020, suggesting potentially faster viral replication and greater infectiousness of Delta during early infection. The estimated transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in 29 donor-recipient transmission pairs. However, the transmission of minor iSNVs resulted in at least 3 of the 34 substitutions that were identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread. |
| format | Online Article Text |
| id | pubmed-8786931 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87869312022-02-07 Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant Li, Baisheng Deng, Aiping Li, Kuibiao Hu, Yao Li, Zhencui Shi, Yaling Xiong, Qianling Liu, Zhe Guo, Qianfang Zou, Lirong Zhang, Huan Zhang, Meng Ouyang, Fangzhu Su, Juan Su, Wenzhe Xu, Jing Lin, Huifang Sun, Jing Peng, Jinju Jiang, Huiming Zhou, Pingping Hu, Ting Luo, Min Zhang, Yingtao Zheng, Huanying Xiao, Jianpeng Liu, Tao Tan, Mingkai Che, Rongfei Zeng, Hanri Zheng, Zhonghua Huang, Yushi Yu, Jianxiang Yi, Lina Wu, Jie Chen, Jingdiao Zhong, Haojie Deng, Xiaoling Kang, Min Pybus, Oliver G. Hall, Matthew Lythgoe, Katrina A. Li, Yan Yuan, Jun He, Jianfeng Lu, Jing Nat Commun Article The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequential PCR testing of quarantined individuals indicated that the viral loads of Delta infections, when they first become PCR-positive, were on average ~1000 times greater compared to lineage A/B infections during the first epidemic wave in China in early 2020, suggesting potentially faster viral replication and greater infectiousness of Delta during early infection. The estimated transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in 29 donor-recipient transmission pairs. However, the transmission of minor iSNVs resulted in at least 3 of the 34 substitutions that were identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread. Nature Publishing Group UK 2022-01-24 /pmc/articles/PMC8786931/ /pubmed/35075154 http://dx.doi.org/10.1038/s41467-022-28089-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Li, Baisheng Deng, Aiping Li, Kuibiao Hu, Yao Li, Zhencui Shi, Yaling Xiong, Qianling Liu, Zhe Guo, Qianfang Zou, Lirong Zhang, Huan Zhang, Meng Ouyang, Fangzhu Su, Juan Su, Wenzhe Xu, Jing Lin, Huifang Sun, Jing Peng, Jinju Jiang, Huiming Zhou, Pingping Hu, Ting Luo, Min Zhang, Yingtao Zheng, Huanying Xiao, Jianpeng Liu, Tao Tan, Mingkai Che, Rongfei Zeng, Hanri Zheng, Zhonghua Huang, Yushi Yu, Jianxiang Yi, Lina Wu, Jie Chen, Jingdiao Zhong, Haojie Deng, Xiaoling Kang, Min Pybus, Oliver G. Hall, Matthew Lythgoe, Katrina A. Li, Yan Yuan, Jun He, Jianfeng Lu, Jing Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant |
| title | Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant |
| title_full | Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant |
| title_fullStr | Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant |
| title_full_unstemmed | Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant |
| title_short | Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant |
| title_sort | viral infection and transmission in a large, well-traced outbreak caused by the sars-cov-2 delta variant |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786931/ https://www.ncbi.nlm.nih.gov/pubmed/35075154 http://dx.doi.org/10.1038/s41467-022-28089-y |
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