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Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment

Vitiligo, an acquired depigmenting disorder of the skin that reacts against normal melanocytes, sometimes occurs as an immune-related adverse event in the treatment of melanoma with immune checkpoint inhibitors. It has been known that the occurrence of vitiligo is associated with a favorable therape...

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Autores principales: Furune, Satoshi, Kondo, Chiaki, Takano, Yuko, Shimokata, Tomoya, Sugishita, Mihoko, Mitsuma, Ayako, Maeda, Osamu, Ando, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787012/
https://www.ncbi.nlm.nih.gov/pubmed/35116218
http://dx.doi.org/10.1007/s13691-021-00515-w
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author Furune, Satoshi
Kondo, Chiaki
Takano, Yuko
Shimokata, Tomoya
Sugishita, Mihoko
Mitsuma, Ayako
Maeda, Osamu
Ando, Yuichi
author_facet Furune, Satoshi
Kondo, Chiaki
Takano, Yuko
Shimokata, Tomoya
Sugishita, Mihoko
Mitsuma, Ayako
Maeda, Osamu
Ando, Yuichi
author_sort Furune, Satoshi
collection PubMed
description Vitiligo, an acquired depigmenting disorder of the skin that reacts against normal melanocytes, sometimes occurs as an immune-related adverse event in the treatment of melanoma with immune checkpoint inhibitors. It has been known that the occurrence of vitiligo is associated with a favorable therapeutic response in patients with melanoma, but it is not yet clear whether the association also applies to amelanotic melanoma, a minor subtype of melanoma with little or no melanin pigmentation. We report a patient with amelanotic melanoma of the esophagus who responded well to nivolumab treatment. Shortly after the tumor response, vitiligo was found on the patient’s forearms. This case suggests that the occurrence of vitiligo is associated with a favorable response to nivolumab treatment for amelanotic melanoma.
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spelling pubmed-87870122022-02-02 Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment Furune, Satoshi Kondo, Chiaki Takano, Yuko Shimokata, Tomoya Sugishita, Mihoko Mitsuma, Ayako Maeda, Osamu Ando, Yuichi Int Cancer Conf J Case Report Vitiligo, an acquired depigmenting disorder of the skin that reacts against normal melanocytes, sometimes occurs as an immune-related adverse event in the treatment of melanoma with immune checkpoint inhibitors. It has been known that the occurrence of vitiligo is associated with a favorable therapeutic response in patients with melanoma, but it is not yet clear whether the association also applies to amelanotic melanoma, a minor subtype of melanoma with little or no melanin pigmentation. We report a patient with amelanotic melanoma of the esophagus who responded well to nivolumab treatment. Shortly after the tumor response, vitiligo was found on the patient’s forearms. This case suggests that the occurrence of vitiligo is associated with a favorable response to nivolumab treatment for amelanotic melanoma. Springer Singapore 2021-10-12 /pmc/articles/PMC8787012/ /pubmed/35116218 http://dx.doi.org/10.1007/s13691-021-00515-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Furune, Satoshi
Kondo, Chiaki
Takano, Yuko
Shimokata, Tomoya
Sugishita, Mihoko
Mitsuma, Ayako
Maeda, Osamu
Ando, Yuichi
Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
title Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
title_full Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
title_fullStr Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
title_full_unstemmed Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
title_short Vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
title_sort vitiligo and tumor response in a patient with amelanotic melanoma undergoing nivolumab treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787012/
https://www.ncbi.nlm.nih.gov/pubmed/35116218
http://dx.doi.org/10.1007/s13691-021-00515-w
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