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Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma

OBJECTIVE: To explore the therapeutic potential and the underlying mechanism of metformin, an adenosine monophosphate‐activated kinase (AMPK) activator, in ocular melanoma. METHODS: CCK8, transwell, and colony formation assays were performed to detect the proliferation and migration ability of ocula...

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Detalles Bibliográficos
Autores principales:	Zhuang, Ai, Chai, Peiwei, Wang, Shaoyun, Zuo, Sipeng, Yu, Jie, Jia, Shichong, Ge, Shengfang, Jia, Renbing, Zhou, Yixiong, Shi, Wodong, Xu, Xiaofang, Ruan, Jing, Fan, Xianqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787022/ https://www.ncbi.nlm.nih.gov/pubmed/35075807 http://dx.doi.org/10.1002/ctm2.660

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