Natural Killer Cells in the Malignant Niche of Multiple Myeloma

Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall potential of NK cells has brought them to the spotlight of targeted immunotherapy in solid and hematological malignancies,...

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Autores principales: Venglar, Ondrej, Bago, Julio Rodriguez, Motais, Benjamin, Hajek, Roman, Jelinek, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787055/
https://www.ncbi.nlm.nih.gov/pubmed/35087536
http://dx.doi.org/10.3389/fimmu.2021.816499
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author Venglar, Ondrej
Bago, Julio Rodriguez
Motais, Benjamin
Hajek, Roman
Jelinek, Tomas
author_facet Venglar, Ondrej
Bago, Julio Rodriguez
Motais, Benjamin
Hajek, Roman
Jelinek, Tomas
author_sort Venglar, Ondrej
collection PubMed
description Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall potential of NK cells has brought them to the spotlight of targeted immunotherapy in solid and hematological malignancies, including multiple myeloma (MM). Nonetheless, NK cells are subjected to a variety of cancer defense mechanisms, leading to impaired maturation, chemotaxis, target recognition, and killing. This review aims to summarize the available and most current knowledge about cancer-related impairment of NK cell function occurring in MM.
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spelling pubmed-87870552022-01-26 Natural Killer Cells in the Malignant Niche of Multiple Myeloma Venglar, Ondrej Bago, Julio Rodriguez Motais, Benjamin Hajek, Roman Jelinek, Tomas Front Immunol Immunology Natural killer (NK) cells represent a subset of CD3- CD7+ CD56+/dim lymphocytes with cytotoxic and suppressor activity against virus-infected cells and cancer cells. The overall potential of NK cells has brought them to the spotlight of targeted immunotherapy in solid and hematological malignancies, including multiple myeloma (MM). Nonetheless, NK cells are subjected to a variety of cancer defense mechanisms, leading to impaired maturation, chemotaxis, target recognition, and killing. This review aims to summarize the available and most current knowledge about cancer-related impairment of NK cell function occurring in MM. Frontiers Media S.A. 2022-01-11 /pmc/articles/PMC8787055/ /pubmed/35087536 http://dx.doi.org/10.3389/fimmu.2021.816499 Text en Copyright © 2022 Venglar, Bago, Motais, Hajek and Jelinek https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Venglar, Ondrej
Bago, Julio Rodriguez
Motais, Benjamin
Hajek, Roman
Jelinek, Tomas
Natural Killer Cells in the Malignant Niche of Multiple Myeloma
title Natural Killer Cells in the Malignant Niche of Multiple Myeloma
title_full Natural Killer Cells in the Malignant Niche of Multiple Myeloma
title_fullStr Natural Killer Cells in the Malignant Niche of Multiple Myeloma
title_full_unstemmed Natural Killer Cells in the Malignant Niche of Multiple Myeloma
title_short Natural Killer Cells in the Malignant Niche of Multiple Myeloma
title_sort natural killer cells in the malignant niche of multiple myeloma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787055/
https://www.ncbi.nlm.nih.gov/pubmed/35087536
http://dx.doi.org/10.3389/fimmu.2021.816499
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