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Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group
Objective: This study aimed to explore the association between uric acid (UA) and blood pressure (BP) in hypertension treatment and non-treatment groups. Methods: A cross-sectional study with 6,985 individuals from the National Health and Nutrition Examination Survey (NHANES) was performed. Multiple...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787103/ https://www.ncbi.nlm.nih.gov/pubmed/35087877 http://dx.doi.org/10.3389/fcvm.2021.751089 |
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author | Ding, Ning Long, Yong Li, Changluo He, Liudang Su, Yingjie |
author_facet | Ding, Ning Long, Yong Li, Changluo He, Liudang Su, Yingjie |
author_sort | Ding, Ning |
collection | PubMed |
description | Objective: This study aimed to explore the association between uric acid (UA) and blood pressure (BP) in hypertension treatment and non-treatment groups. Methods: A cross-sectional study with 6,985 individuals from the National Health and Nutrition Examination Survey (NHANES) was performed. Multiple linear regression analysis was performed to explore the relationship of UA and BP in hypertension between the treatment group (n = 5,983) and the non-treatment group (n = 1,002). Results: A significantly negative association was discovered in SBP (β, −0.36 [95% CI, −0.71, −0.01]) and DBP (β, −0.47 [95% CI, −0.69, −0.26]) in the hypertension treatment group. In the hypertension non-treatment group, the associations between UA and BP including SBP, DBP were both an inverted U-shape. The inflection point of SBP and DBP was 7 and 7.5 mg/dl, respectively. For SBP, the association was positively significant (β, 3.11 [95% CI, 1.67, 4.56]) before the inflection point of 7 mg/dl. However, after the inflection point of 7 mg/dl, the association was negative (β, −5.44 [95% CI, −8.6, −2.28]). For DBP, the inflection point was 7.5 mg/dl, and the effect size was positive (β, 1.19 [95% CI, 0.37, 2.01]) before the inflection point. However, after it, the effect size was negative (β, −3.24 [95% CI, −5.72, −0.76]). Conclusion: The association between UA and BP was negative in the hypertension treatment group. In the hypertension non-treatment group, the associations between UA and BP including SBP and DBP were both an inverted U-shape. |
format | Online Article Text |
id | pubmed-8787103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87871032022-01-26 Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group Ding, Ning Long, Yong Li, Changluo He, Liudang Su, Yingjie Front Cardiovasc Med Cardiovascular Medicine Objective: This study aimed to explore the association between uric acid (UA) and blood pressure (BP) in hypertension treatment and non-treatment groups. Methods: A cross-sectional study with 6,985 individuals from the National Health and Nutrition Examination Survey (NHANES) was performed. Multiple linear regression analysis was performed to explore the relationship of UA and BP in hypertension between the treatment group (n = 5,983) and the non-treatment group (n = 1,002). Results: A significantly negative association was discovered in SBP (β, −0.36 [95% CI, −0.71, −0.01]) and DBP (β, −0.47 [95% CI, −0.69, −0.26]) in the hypertension treatment group. In the hypertension non-treatment group, the associations between UA and BP including SBP, DBP were both an inverted U-shape. The inflection point of SBP and DBP was 7 and 7.5 mg/dl, respectively. For SBP, the association was positively significant (β, 3.11 [95% CI, 1.67, 4.56]) before the inflection point of 7 mg/dl. However, after the inflection point of 7 mg/dl, the association was negative (β, −5.44 [95% CI, −8.6, −2.28]). For DBP, the inflection point was 7.5 mg/dl, and the effect size was positive (β, 1.19 [95% CI, 0.37, 2.01]) before the inflection point. However, after it, the effect size was negative (β, −3.24 [95% CI, −5.72, −0.76]). Conclusion: The association between UA and BP was negative in the hypertension treatment group. In the hypertension non-treatment group, the associations between UA and BP including SBP and DBP were both an inverted U-shape. Frontiers Media S.A. 2022-01-11 /pmc/articles/PMC8787103/ /pubmed/35087877 http://dx.doi.org/10.3389/fcvm.2021.751089 Text en Copyright © 2022 Ding, Long, Li, He and Su. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Ding, Ning Long, Yong Li, Changluo He, Liudang Su, Yingjie Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group |
title | Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group |
title_full | Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group |
title_fullStr | Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group |
title_full_unstemmed | Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group |
title_short | Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group |
title_sort | association of uric acid with blood pressure in hypertension between treatment group and non-treatment group |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787103/ https://www.ncbi.nlm.nih.gov/pubmed/35087877 http://dx.doi.org/10.3389/fcvm.2021.751089 |
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