Nanotechnology in Drug Delivery for Liver Fibrosis

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects...

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Detalles Bibliográficos
Autores principales: Gu, Lihong, Zhang, Feng, Wu, Jinhui, Zhuge, Yuzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787125/
https://www.ncbi.nlm.nih.gov/pubmed/35087870
http://dx.doi.org/10.3389/fmolb.2021.804396
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author Gu, Lihong
Zhang, Feng
Wu, Jinhui
Zhuge, Yuzheng
author_facet Gu, Lihong
Zhang, Feng
Wu, Jinhui
Zhuge, Yuzheng
author_sort Gu, Lihong
collection PubMed
description Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment.
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spelling pubmed-87871252022-01-26 Nanotechnology in Drug Delivery for Liver Fibrosis Gu, Lihong Zhang, Feng Wu, Jinhui Zhuge, Yuzheng Front Mol Biosci Molecular Biosciences Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment. Frontiers Media S.A. 2022-01-11 /pmc/articles/PMC8787125/ /pubmed/35087870 http://dx.doi.org/10.3389/fmolb.2021.804396 Text en Copyright © 2022 Gu, Zhang, Wu and Zhuge. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Gu, Lihong
Zhang, Feng
Wu, Jinhui
Zhuge, Yuzheng
Nanotechnology in Drug Delivery for Liver Fibrosis
title Nanotechnology in Drug Delivery for Liver Fibrosis
title_full Nanotechnology in Drug Delivery for Liver Fibrosis
title_fullStr Nanotechnology in Drug Delivery for Liver Fibrosis
title_full_unstemmed Nanotechnology in Drug Delivery for Liver Fibrosis
title_short Nanotechnology in Drug Delivery for Liver Fibrosis
title_sort nanotechnology in drug delivery for liver fibrosis
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787125/
https://www.ncbi.nlm.nih.gov/pubmed/35087870
http://dx.doi.org/10.3389/fmolb.2021.804396
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