UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.

Herein, we tested the ability of UNC-33L to rescue dauer formation, lifespan, and locomotion defects of unc-33(mn407) mutants. Results show that the presence of UNC-33L does not rescue the defective dauer phenotype in unc-33(mn407) mutants. However, UNC-33L significantly rescued premature death and...

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Detalles Bibliográficos
Autores principales: Lopez, Melissa E, Vacio, Arianna M, Cantu, Jason, Holgado, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787492/
https://www.ncbi.nlm.nih.gov/pubmed/35088044
http://dx.doi.org/10.17912/micropub.biology.000515
Descripción
Sumario:Herein, we tested the ability of UNC-33L to rescue dauer formation, lifespan, and locomotion defects of unc-33(mn407) mutants. Results show that the presence of UNC-33L does not rescue the defective dauer phenotype in unc-33(mn407) mutants. However, UNC-33L significantly rescued premature death and uncoordinated locomotion in young unc-33(mn407) adults. The degree of UNC-33L-mediated rescue was less noticeable as the nematodes aged, denoting that both age and the presence of UNC-33L interact in the production of the phenotypes.

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