UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.

Herein, we tested the ability of UNC-33L to rescue dauer formation, lifespan, and locomotion defects of unc-33(mn407) mutants. Results show that the presence of UNC-33L does not rescue the defective dauer phenotype in unc-33(mn407) mutants. However, UNC-33L significantly rescued premature death and...

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Detalles Bibliográficos
Autores principales: Lopez, Melissa E, Vacio, Arianna M, Cantu, Jason, Holgado, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787492/
https://www.ncbi.nlm.nih.gov/pubmed/35088044
http://dx.doi.org/10.17912/micropub.biology.000515
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author Lopez, Melissa E
Vacio, Arianna M
Cantu, Jason
Holgado, Andrea
author_facet Lopez, Melissa E
Vacio, Arianna M
Cantu, Jason
Holgado, Andrea
author_sort Lopez, Melissa E
collection PubMed
description Herein, we tested the ability of UNC-33L to rescue dauer formation, lifespan, and locomotion defects of unc-33(mn407) mutants. Results show that the presence of UNC-33L does not rescue the defective dauer phenotype in unc-33(mn407) mutants. However, UNC-33L significantly rescued premature death and uncoordinated locomotion in young unc-33(mn407) adults. The degree of UNC-33L-mediated rescue was less noticeable as the nematodes aged, denoting that both age and the presence of UNC-33L interact in the production of the phenotypes.
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spelling pubmed-87874922022-01-26 UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects. Lopez, Melissa E Vacio, Arianna M Cantu, Jason Holgado, Andrea MicroPubl Biol New Finding Herein, we tested the ability of UNC-33L to rescue dauer formation, lifespan, and locomotion defects of unc-33(mn407) mutants. Results show that the presence of UNC-33L does not rescue the defective dauer phenotype in unc-33(mn407) mutants. However, UNC-33L significantly rescued premature death and uncoordinated locomotion in young unc-33(mn407) adults. The degree of UNC-33L-mediated rescue was less noticeable as the nematodes aged, denoting that both age and the presence of UNC-33L interact in the production of the phenotypes. Caltech Library 2022-01-24 /pmc/articles/PMC8787492/ /pubmed/35088044 http://dx.doi.org/10.17912/micropub.biology.000515 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Lopez, Melissa E
Vacio, Arianna M
Cantu, Jason
Holgado, Andrea
UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
title UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
title_full UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
title_fullStr UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
title_full_unstemmed UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
title_short UNC-33L partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
title_sort unc-33l partially rescues life span and locomotion defects in unc-33 mutants but fails to rescue dauer formation defects.
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787492/
https://www.ncbi.nlm.nih.gov/pubmed/35088044
http://dx.doi.org/10.17912/micropub.biology.000515
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