Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura

Cancer-related microangiopathic hemolytic anemia (MAHA) is a rare and life-threatening condition. We present a patient who had been treated for invasive lobular breast carcinoma in clinical remission with fever and hemolytic anemia. The peripheral blood film showed MAHA and thrombocytopenia, and a f...

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Autores principales: Chong, Siew Lian, Ahmad Asnawi, Asral Wirda, Hamzah, Roszymah, Liew, Pek Kuen, Ong, Tee Chuan, Tan, Sen Mui, Chang, Kian Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787534/
https://www.ncbi.nlm.nih.gov/pubmed/35111014
http://dx.doi.org/10.1159/000521159
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author Chong, Siew Lian
Ahmad Asnawi, Asral Wirda
Hamzah, Roszymah
Liew, Pek Kuen
Ong, Tee Chuan
Tan, Sen Mui
Chang, Kian Meng
author_facet Chong, Siew Lian
Ahmad Asnawi, Asral Wirda
Hamzah, Roszymah
Liew, Pek Kuen
Ong, Tee Chuan
Tan, Sen Mui
Chang, Kian Meng
author_sort Chong, Siew Lian
collection PubMed
description Cancer-related microangiopathic hemolytic anemia (MAHA) is a rare and life-threatening condition. We present a patient who had been treated for invasive lobular breast carcinoma in clinical remission with fever and hemolytic anemia. The peripheral blood film showed MAHA and thrombocytopenia, and a functional deficiency of ADAMTS13 activity of 23% consistent with acquired thrombotic thrombocytopenic purpura. Bone marrow aspirate and trephine biopsy confirmed metastatic carcinoma. Further evaluation revealed the involvement of multiple bone sites without recurrence of the primary tumor. The patient received a daily plasma exchange with cryosupernatant and was pulsed with corticosteroids. MAHA related to breast cancer appears to be a rare occurrence.
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spelling pubmed-87875342022-02-01 Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura Chong, Siew Lian Ahmad Asnawi, Asral Wirda Hamzah, Roszymah Liew, Pek Kuen Ong, Tee Chuan Tan, Sen Mui Chang, Kian Meng Case Rep Oncol Case Report Cancer-related microangiopathic hemolytic anemia (MAHA) is a rare and life-threatening condition. We present a patient who had been treated for invasive lobular breast carcinoma in clinical remission with fever and hemolytic anemia. The peripheral blood film showed MAHA and thrombocytopenia, and a functional deficiency of ADAMTS13 activity of 23% consistent with acquired thrombotic thrombocytopenic purpura. Bone marrow aspirate and trephine biopsy confirmed metastatic carcinoma. Further evaluation revealed the involvement of multiple bone sites without recurrence of the primary tumor. The patient received a daily plasma exchange with cryosupernatant and was pulsed with corticosteroids. MAHA related to breast cancer appears to be a rare occurrence. S. Karger AG 2021-12-27 /pmc/articles/PMC8787534/ /pubmed/35111014 http://dx.doi.org/10.1159/000521159 Text en Copyright © 2021 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Chong, Siew Lian
Ahmad Asnawi, Asral Wirda
Hamzah, Roszymah
Liew, Pek Kuen
Ong, Tee Chuan
Tan, Sen Mui
Chang, Kian Meng
Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura
title Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura
title_full Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura
title_fullStr Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura
title_full_unstemmed Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura
title_short Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura
title_sort occult disseminated metastatic breast carcinoma presenting as acquired thrombotic thrombocytopenic purpura
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787534/
https://www.ncbi.nlm.nih.gov/pubmed/35111014
http://dx.doi.org/10.1159/000521159
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