Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma

Carotid body paraganglioma is a rare neuroendocrine tumor presenting with low-grade histological and clinical features. However, the tumor has the potential to produce distant metastasis, and due to its rarity, little information is available regarding chemotherapy for such metastatic lesions. Here,...

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Autores principales: Yamada, Hiroki, Fukushima, Toshirou, Kobayashi, Takashi, Kanda, Shintaro, Koizumi, Tomonobu, Iwaya, Mai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787577/
https://www.ncbi.nlm.nih.gov/pubmed/35111016
http://dx.doi.org/10.1159/000520851
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author Yamada, Hiroki
Fukushima, Toshirou
Kobayashi, Takashi
Kanda, Shintaro
Koizumi, Tomonobu
Iwaya, Mai
author_facet Yamada, Hiroki
Fukushima, Toshirou
Kobayashi, Takashi
Kanda, Shintaro
Koizumi, Tomonobu
Iwaya, Mai
author_sort Yamada, Hiroki
collection PubMed
description Carotid body paraganglioma is a rare neuroendocrine tumor presenting with low-grade histological and clinical features. However, the tumor has the potential to produce distant metastasis, and due to its rarity, little information is available regarding chemotherapy for such metastatic lesions. Here, we report a case of carotid body paraganglioma with development of pulmonary and bone metastases 10 years after radical surgery for the primary lesion in the neck. The lesions showed a good response to cyclophosphamide, vincristine, and dacarbazine chemotherapy. A beneficial therapeutic outcome by chemotherapy is extremely rare in patients with metastatic carotid body paraganglioma.
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spelling pubmed-87875772022-02-01 Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma Yamada, Hiroki Fukushima, Toshirou Kobayashi, Takashi Kanda, Shintaro Koizumi, Tomonobu Iwaya, Mai Case Rep Oncol Case Report Carotid body paraganglioma is a rare neuroendocrine tumor presenting with low-grade histological and clinical features. However, the tumor has the potential to produce distant metastasis, and due to its rarity, little information is available regarding chemotherapy for such metastatic lesions. Here, we report a case of carotid body paraganglioma with development of pulmonary and bone metastases 10 years after radical surgery for the primary lesion in the neck. The lesions showed a good response to cyclophosphamide, vincristine, and dacarbazine chemotherapy. A beneficial therapeutic outcome by chemotherapy is extremely rare in patients with metastatic carotid body paraganglioma. S. Karger AG 2021-12-27 /pmc/articles/PMC8787577/ /pubmed/35111016 http://dx.doi.org/10.1159/000520851 Text en Copyright © 2021 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Yamada, Hiroki
Fukushima, Toshirou
Kobayashi, Takashi
Kanda, Shintaro
Koizumi, Tomonobu
Iwaya, Mai
Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma
title Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma
title_full Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma
title_fullStr Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma
title_full_unstemmed Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma
title_short Successful Response to Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy in a Patient with Metastatic Carotid Body Paraganglioma
title_sort successful response to cyclophosphamide, vincristine, and dacarbazine chemotherapy in a patient with metastatic carotid body paraganglioma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787577/
https://www.ncbi.nlm.nih.gov/pubmed/35111016
http://dx.doi.org/10.1159/000520851
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