Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome

Endogenous endophthalmitis caused by Aspergillus species tends to be very aggressive, often leading to devastating visual outcomes. Historically, intravitreal amphotericin injections have played a central role in management, but with variable visual outcomes and a risk of toxicity. Limited reports s...

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Autores principales: Aboobakar, Inas F., Ong, Sally S., Nti, Akosua, Jiramongkolchai, Kim, Arevalo, J. Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787620/
https://www.ncbi.nlm.nih.gov/pubmed/35111037
http://dx.doi.org/10.1159/000520819
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author Aboobakar, Inas F.
Ong, Sally S.
Nti, Akosua
Jiramongkolchai, Kim
Arevalo, J. Fernando
author_facet Aboobakar, Inas F.
Ong, Sally S.
Nti, Akosua
Jiramongkolchai, Kim
Arevalo, J. Fernando
author_sort Aboobakar, Inas F.
collection PubMed
description Endogenous endophthalmitis caused by Aspergillus species tends to be very aggressive, often leading to devastating visual outcomes. Historically, intravitreal amphotericin injections have played a central role in management, but with variable visual outcomes and a risk of toxicity. Limited reports suggest that use of intravitreal voriconazole is a safe and efficacious alternative, though these cases were treated with only few intravitreal injections. Here, we report a case of bilateral endogenous Aspergillus endophthalmitis treated with 8 intravitreal voriconazole injections in the right eye and 11 in the left eye with good best-corrected final visual outcome (20/50 right eye and 20/40 left eye).
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spelling pubmed-87876202022-02-01 Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome Aboobakar, Inas F. Ong, Sally S. Nti, Akosua Jiramongkolchai, Kim Arevalo, J. Fernando Case Rep Ophthalmol Case Report Endogenous endophthalmitis caused by Aspergillus species tends to be very aggressive, often leading to devastating visual outcomes. Historically, intravitreal amphotericin injections have played a central role in management, but with variable visual outcomes and a risk of toxicity. Limited reports suggest that use of intravitreal voriconazole is a safe and efficacious alternative, though these cases were treated with only few intravitreal injections. Here, we report a case of bilateral endogenous Aspergillus endophthalmitis treated with 8 intravitreal voriconazole injections in the right eye and 11 in the left eye with good best-corrected final visual outcome (20/50 right eye and 20/40 left eye). S. Karger AG 2021-12-30 /pmc/articles/PMC8787620/ /pubmed/35111037 http://dx.doi.org/10.1159/000520819 Text en Copyright © 2021 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Aboobakar, Inas F.
Ong, Sally S.
Nti, Akosua
Jiramongkolchai, Kim
Arevalo, J. Fernando
Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome
title Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome
title_full Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome
title_fullStr Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome
title_full_unstemmed Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome
title_short Treatment of Bilateral Endogenous Aspergillus Endophthalmitis with Multiple Intravitreal Voriconazole Injections with Good Visual Outcome
title_sort treatment of bilateral endogenous aspergillus endophthalmitis with multiple intravitreal voriconazole injections with good visual outcome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787620/
https://www.ncbi.nlm.nih.gov/pubmed/35111037
http://dx.doi.org/10.1159/000520819
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