Nos2(−/−) mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis

BACKGROUND: Understanding the pathophysiology of central nervous system tuberculosis (CNS-TB) is hampered by the lack of a good pre-clinical model that mirrors the human CNS-TB infection. We developed a murine CNS-TB model that demonstrates neurobehavioral changes with similar immunopathology with h...

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Detalles Bibliográficos
Autores principales: Poh, Xuan Ying, Hong, Jia Mei, Bai, Chen, Miow, Qing Hao, Thong, Pei Min, Wang, Yu, Rajarethinam, Ravisankar, Ding, Cristine S. L., Ong, Catherine W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787888/
https://www.ncbi.nlm.nih.gov/pubmed/35073927
http://dx.doi.org/10.1186/s12974-022-02387-0

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