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Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning
BACKGROUND: Although the total number of suicides decreased since the beginning of the 1980s, the number of suicide-related behaviors using self-intoxication increased. Therefore, research on the characteristics of individuals committing self-intoxication becomes of growing importance for risk asses...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788074/ https://www.ncbi.nlm.nih.gov/pubmed/35073945 http://dx.doi.org/10.1186/s13033-021-00513-8 |
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author | Geith, Stefanie Didden, Christiane Rabe, Christian Zellner, Tobias Ott, Armin Eyer, Florian |
author_facet | Geith, Stefanie Didden, Christiane Rabe, Christian Zellner, Tobias Ott, Armin Eyer, Florian |
author_sort | Geith, Stefanie |
collection | PubMed |
description | BACKGROUND: Although the total number of suicides decreased since the beginning of the 1980s, the number of suicide-related behaviors using self-intoxication increased. Therefore, research on the characteristics of individuals committing self-intoxication becomes of growing importance for risk assessments and the development of preventive measures. METHODS: In this prospective, observational, monocentric cohort study, all incoming calls at our Poisons Control Centre reporting suicide-related behaviors through self-intoxication, were analyzed via a standardized questionnaire over 12 months. Both univariate and bivariate analyses were performed. RESULTS: 1238 cases of deliberate intoxication were included in the study. The majority of cases occurred in the age group between 18 and 44 (n = 607/49%), two-thirds were female (n = 817/66%). The main substances used were antidepressants (n = 420/34%), peripheral analgesics (n = 322/26%) and neuroleptics (n = 282/23%). The majority of patients ingested substances from their prescribed medication (n = 640/82%) with the highest proportion in those aged over 64 years (n = 72/113; 91%, p < 0.001). Substance use was reported for the minority of patients (n = 175/23%). For 704 cases (79%), a psychiatric disorder was documented. Factors associated with recurrent suicide-related behaviors were an underlying psychiatric disorder (OR = 6.2; 95% CI 3.8–10.4), substance use (OR = 2.4; 95% CI 1.5–3.8), and ingestion of neuroleptics (OR = 2.1, 95% CI 1.4–3.0) or antidepressants (OR = 1.6; 95% CI 1.2–2.3). CONCLUSION: This study might contribute to identifying individuals with an increased risk of suicide-related behaviors by deliberate intoxication and to developing preventive strategies for future suicide attempt(s). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13033-021-00513-8. |
format | Online Article Text |
id | pubmed-8788074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-87880742022-02-03 Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning Geith, Stefanie Didden, Christiane Rabe, Christian Zellner, Tobias Ott, Armin Eyer, Florian Int J Ment Health Syst Research BACKGROUND: Although the total number of suicides decreased since the beginning of the 1980s, the number of suicide-related behaviors using self-intoxication increased. Therefore, research on the characteristics of individuals committing self-intoxication becomes of growing importance for risk assessments and the development of preventive measures. METHODS: In this prospective, observational, monocentric cohort study, all incoming calls at our Poisons Control Centre reporting suicide-related behaviors through self-intoxication, were analyzed via a standardized questionnaire over 12 months. Both univariate and bivariate analyses were performed. RESULTS: 1238 cases of deliberate intoxication were included in the study. The majority of cases occurred in the age group between 18 and 44 (n = 607/49%), two-thirds were female (n = 817/66%). The main substances used were antidepressants (n = 420/34%), peripheral analgesics (n = 322/26%) and neuroleptics (n = 282/23%). The majority of patients ingested substances from their prescribed medication (n = 640/82%) with the highest proportion in those aged over 64 years (n = 72/113; 91%, p < 0.001). Substance use was reported for the minority of patients (n = 175/23%). For 704 cases (79%), a psychiatric disorder was documented. Factors associated with recurrent suicide-related behaviors were an underlying psychiatric disorder (OR = 6.2; 95% CI 3.8–10.4), substance use (OR = 2.4; 95% CI 1.5–3.8), and ingestion of neuroleptics (OR = 2.1, 95% CI 1.4–3.0) or antidepressants (OR = 1.6; 95% CI 1.2–2.3). CONCLUSION: This study might contribute to identifying individuals with an increased risk of suicide-related behaviors by deliberate intoxication and to developing preventive strategies for future suicide attempt(s). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13033-021-00513-8. BioMed Central 2022-01-25 /pmc/articles/PMC8788074/ /pubmed/35073945 http://dx.doi.org/10.1186/s13033-021-00513-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Geith, Stefanie Didden, Christiane Rabe, Christian Zellner, Tobias Ott, Armin Eyer, Florian Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
title | Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
title_full | Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
title_fullStr | Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
title_full_unstemmed | Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
title_short | Lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
title_sort | lessons to be learned: identifying high-risk medication and circumstances in patients at risk for suicidal self-poisoning |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788074/ https://www.ncbi.nlm.nih.gov/pubmed/35073945 http://dx.doi.org/10.1186/s13033-021-00513-8 |
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