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Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases

Patients with Gorham–Stout disease (GSD) present progressive destruction and resorption of bone. Typical bone-related symptoms include swelling, pain and functional impairment in the region involved. The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblas...

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Autores principales: Angelini, Andrea, Mosele, Nicolò, Pagliarini, Elisa, Ruggieri, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788153/
https://www.ncbi.nlm.nih.gov/pubmed/35076412
http://dx.doi.org/10.1530/EOR-21-0083
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author Angelini, Andrea
Mosele, Nicolò
Pagliarini, Elisa
Ruggieri, Pietro
author_facet Angelini, Andrea
Mosele, Nicolò
Pagliarini, Elisa
Ruggieri, Pietro
author_sort Angelini, Andrea
collection PubMed
description Patients with Gorham–Stout disease (GSD) present progressive destruction and resorption of bone. Typical bone-related symptoms include swelling, pain and functional impairment in the region involved. The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblast function. Multi-targeted pharmacological approach includes innovative options and represent milestones of treatment, sometimes associated with radiotherapy. Surgery is mainly used to treat complications: pathologic/impending fractures, spinal instability or deformities and chylothorax. In this narrative review, we highlight current standards in diagnosis, clinical management and therapeutic strategies.
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spelling pubmed-87881532022-01-28 Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases Angelini, Andrea Mosele, Nicolò Pagliarini, Elisa Ruggieri, Pietro EFORT Open Rev General Orthopaedics Patients with Gorham–Stout disease (GSD) present progressive destruction and resorption of bone. Typical bone-related symptoms include swelling, pain and functional impairment in the region involved. The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblast function. Multi-targeted pharmacological approach includes innovative options and represent milestones of treatment, sometimes associated with radiotherapy. Surgery is mainly used to treat complications: pathologic/impending fractures, spinal instability or deformities and chylothorax. In this narrative review, we highlight current standards in diagnosis, clinical management and therapeutic strategies. Bioscientifica Ltd 2022-01-11 /pmc/articles/PMC8788153/ /pubmed/35076412 http://dx.doi.org/10.1530/EOR-21-0083 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle General Orthopaedics
Angelini, Andrea
Mosele, Nicolò
Pagliarini, Elisa
Ruggieri, Pietro
Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases
title Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases
title_full Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases
title_fullStr Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases
title_full_unstemmed Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases
title_short Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases
title_sort current concepts from diagnosis to management in gorham–stout disease: a systematic narrative review of about 350 cases
topic General Orthopaedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788153/
https://www.ncbi.nlm.nih.gov/pubmed/35076412
http://dx.doi.org/10.1530/EOR-21-0083
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