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Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication
In SARS-CoV-2, at the S1/S2 furin cleavage site, a four amino acid insert (P-R-R-A) not found in closely related corona viruses, has been shown to facilitate entry into respiratory epithelial cells and promote virus transmission, infectivity and virulence. By cupric aerosol treatment, complexation o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788156/ https://www.ncbi.nlm.nih.gov/pubmed/35095175 http://dx.doi.org/10.1016/j.mehy.2022.110775 |
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author | Deloncle, Roger Guillard, Olivier Pineau, Alain Lesage, Gérard |
author_facet | Deloncle, Roger Guillard, Olivier Pineau, Alain Lesage, Gérard |
author_sort | Deloncle, Roger |
collection | PubMed |
description | In SARS-CoV-2, at the S1/S2 furin cleavage site, a four amino acid insert (P-R-R-A) not found in closely related corona viruses, has been shown to facilitate entry into respiratory epithelial cells and promote virus transmission, infectivity and virulence. By cupric aerosol treatment, complexation of these four amino acids (-P-R-R-A-), at the spike (S) protein site will lead to a conformational change possibly impeding SARS-CoV-2 replication process in the respiratory track. Since these four amino acids yield strong and stable copper complexes, subsequent to a steric hindrance, this complexation will disturb the furin-like protease cleavage at the spike protein site as it has been recently shown in vitro with copper gluconate. The compilation of stability constants for copper amino-acid complex formation, showing values of the same order of magnitude for all the twenty proteinogenic amino-acids demonstrate thermodynamically that copper amino-acid chelation for SARS-CoV-2 virus will not be affected by mutations leading to amino acid exchanges in the spike protein region. Given its low toxicity, and its very low stability formation constant, copper acetate is proposed rather than copper gluconate for possible cupric aerosol or nasal spray treatments aimed at impeding SARS-CoV-2 multiplication. It will open different medical perspectives, complementary to vaccination, in the fight against COVID 19 native virus, variants and future mutants. |
format | Online Article Text |
id | pubmed-8788156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87881562022-01-25 Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication Deloncle, Roger Guillard, Olivier Pineau, Alain Lesage, Gérard Med Hypotheses Article In SARS-CoV-2, at the S1/S2 furin cleavage site, a four amino acid insert (P-R-R-A) not found in closely related corona viruses, has been shown to facilitate entry into respiratory epithelial cells and promote virus transmission, infectivity and virulence. By cupric aerosol treatment, complexation of these four amino acids (-P-R-R-A-), at the spike (S) protein site will lead to a conformational change possibly impeding SARS-CoV-2 replication process in the respiratory track. Since these four amino acids yield strong and stable copper complexes, subsequent to a steric hindrance, this complexation will disturb the furin-like protease cleavage at the spike protein site as it has been recently shown in vitro with copper gluconate. The compilation of stability constants for copper amino-acid complex formation, showing values of the same order of magnitude for all the twenty proteinogenic amino-acids demonstrate thermodynamically that copper amino-acid chelation for SARS-CoV-2 virus will not be affected by mutations leading to amino acid exchanges in the spike protein region. Given its low toxicity, and its very low stability formation constant, copper acetate is proposed rather than copper gluconate for possible cupric aerosol or nasal spray treatments aimed at impeding SARS-CoV-2 multiplication. It will open different medical perspectives, complementary to vaccination, in the fight against COVID 19 native virus, variants and future mutants. The Author(s). Published by Elsevier Ltd. 2022-03 2022-01-25 /pmc/articles/PMC8788156/ /pubmed/35095175 http://dx.doi.org/10.1016/j.mehy.2022.110775 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Deloncle, Roger Guillard, Olivier Pineau, Alain Lesage, Gérard Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication |
title | Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication |
title_full | Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication |
title_fullStr | Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication |
title_full_unstemmed | Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication |
title_short | Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication |
title_sort | copper acetate aerosols: a possible tool complementary to vaccination in fight against sars-cov-2 and variants replication |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788156/ https://www.ncbi.nlm.nih.gov/pubmed/35095175 http://dx.doi.org/10.1016/j.mehy.2022.110775 |
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