Iron homeostasis pathway DNA methylation trajectories reveal a role for STEAP3 metalloreductase in patient outcomes after aneurysmal subarachnoid hemorrhage

BACKGROUND: Following aneurysmal subarachnoid hemorrhage (aSAH), the brain is susceptible to ferroptosis, a type of iron-dependent cell death. Therapeutic intervention targeting the iron homeostasis pathway shows promise for mitigating ferroptosis and improving recovery in animal models, but little...

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Detalles Bibliográficos
Autores principales: Heinsberg, Lacey W., Weeks, Daniel E., Alexander, Sheila A., Minster, Ryan L., Sherwood, Paula R., Poloyac, Samuel M., Deslouches, Sandra, Crago, Elizabeth A., Conley, Yvette P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788201/
https://www.ncbi.nlm.nih.gov/pubmed/35083470
http://dx.doi.org/10.1186/s43682-021-00003-5

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