High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer

BACKGROUND: While the likelihood of identifying constitutional breast cancer-associated BRCA1, BRCA2 and TP53 pathogenic variants (PVs) increases with earlier diagnosis age, little is known about the correlation with age at diagnosis in other predisposition genes. Here, we assessed the contribution...

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Detalles Bibliográficos
Autores principales: Evans, D Gareth, van Veen, Elke Maria, Byers, Helen J, Evans, Sarah J, Burghel, George J, Woodward, Emma Roisin, Harkness, Elaine F, Eccles, Diana M, Greville-Haygate, Stephanie L, Ellingford, Jamie M, Bowers, Naomi L, Pereira, Marta, Wallace, Andrew J, Howell, Sasha J, Howell, Anthony, Lalloo, Fiona, Newman, William G, Smith, Miriam Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Cancer Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788257/
https://www.ncbi.nlm.nih.gov/pubmed/33758026
http://dx.doi.org/10.1136/jmedgenet-2020-107347

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