Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study

BACKGROUND: Current melphalan-based intravitreal regimens for retinoblastoma (RB) vitreous seeds cause retinal toxicity. We assessed the efficacy and toxicity of topotecan monotherapy compared with melphalan in our rabbit model and patient cohort. METHODS: Rabbit experiments: empiric pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Bogan, Carley M, Kaczmarek, Jessica V, Pierce, Janene M, Chen, Sheau-chiann, Boyd, Kelli L, Calcutt, Marion W, Bridges, Thomas M, Lindsley, Craig W, Nadelmann, Jennifer B, Liao, Albert, Hsieh, Terry, Abramson, David H, Francis, Jasmine H, Friedman, Debra L, Richmond, Ann, Daniels, Anthony B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Laboratory Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788260/
https://www.ncbi.nlm.nih.gov/pubmed/33972235
http://dx.doi.org/10.1136/bjophthalmol-2020-318529

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