Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhibitors based on the structural optimisation of pre...

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Detalles Bibliográficos
Autores principales: Im, Daseul, Jun, Joonhong, Baek, Jihyun, Kim, Haejin, Kang, Dahyun, Bae, Hyunah, Cho, Hyunwook, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788362/
https://www.ncbi.nlm.nih.gov/pubmed/35067150
http://dx.doi.org/10.1080/14756366.2021.2020772

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