Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles

BACKGROUND: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. AIM OF THE STUDY: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. METHODS: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with...

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Detalles Bibliográficos
Autores principales: Bañó-Polo, Manuel, Martínez-Gil, Luis, Sánchez del Pino, Manuel M., Massoli, Alberto, Mingarro, Ismael, Léon, Rubén, Garcia-Murria, Maria Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788378/
https://www.ncbi.nlm.nih.gov/pubmed/35087641
http://dx.doi.org/10.1080/20002297.2022.2030094
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author Bañó-Polo, Manuel
Martínez-Gil, Luis
Sánchez del Pino, Manuel M.
Massoli, Alberto
Mingarro, Ismael
Léon, Rubén
Garcia-Murria, Maria Jesus
author_facet Bañó-Polo, Manuel
Martínez-Gil, Luis
Sánchez del Pino, Manuel M.
Massoli, Alberto
Mingarro, Ismael
Léon, Rubén
Garcia-Murria, Maria Jesus
author_sort Bañó-Polo, Manuel
collection PubMed
description BACKGROUND: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. AIM OF THE STUDY: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. METHODS: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. RESULTS: Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. CONCLUSION: Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
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spelling pubmed-87883782022-01-26 Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles Bañó-Polo, Manuel Martínez-Gil, Luis Sánchez del Pino, Manuel M. Massoli, Alberto Mingarro, Ismael Léon, Rubén Garcia-Murria, Maria Jesus J Oral Microbiol Original Article BACKGROUND: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. AIM OF THE STUDY: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. METHODS: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. RESULTS: Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. CONCLUSION: Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading. Taylor & Francis 2022-01-24 /pmc/articles/PMC8788378/ /pubmed/35087641 http://dx.doi.org/10.1080/20002297.2022.2030094 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bañó-Polo, Manuel
Martínez-Gil, Luis
Sánchez del Pino, Manuel M.
Massoli, Alberto
Mingarro, Ismael
Léon, Rubén
Garcia-Murria, Maria Jesus
Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
title Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
title_full Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
title_fullStr Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
title_full_unstemmed Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
title_short Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
title_sort cetylpyridinium chloride promotes disaggregation of sars-cov-2 virus-like particles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788378/
https://www.ncbi.nlm.nih.gov/pubmed/35087641
http://dx.doi.org/10.1080/20002297.2022.2030094
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