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Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease

The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly occurring in patients aged 65 years or older. The main cause of death in these patients is cardiovascular disease (CVD). Novel markers of vascular integrity may thus be of clinical value for identifying patients at hi...

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Autores principales: Zhao, Qiao, Nooren, Sabine J. L., Zijlstra, Laurien E., Westenberg, Jos J. M., Kroft, Lucia J. M., Jukema, J. Wouter, Berkhout-Byrne, Noeleen C., Rabelink, Ton J., van Zonneveld, Anton Jan, van Buren, Marjolijn, Mooijaart, Simon P., Bijkerk, Roel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788543/
https://www.ncbi.nlm.nih.gov/pubmed/35076541
http://dx.doi.org/10.3390/ncrna8010002
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author Zhao, Qiao
Nooren, Sabine J. L.
Zijlstra, Laurien E.
Westenberg, Jos J. M.
Kroft, Lucia J. M.
Jukema, J. Wouter
Berkhout-Byrne, Noeleen C.
Rabelink, Ton J.
van Zonneveld, Anton Jan
van Buren, Marjolijn
Mooijaart, Simon P.
Bijkerk, Roel
author_facet Zhao, Qiao
Nooren, Sabine J. L.
Zijlstra, Laurien E.
Westenberg, Jos J. M.
Kroft, Lucia J. M.
Jukema, J. Wouter
Berkhout-Byrne, Noeleen C.
Rabelink, Ton J.
van Zonneveld, Anton Jan
van Buren, Marjolijn
Mooijaart, Simon P.
Bijkerk, Roel
author_sort Zhao, Qiao
collection PubMed
description The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly occurring in patients aged 65 years or older. The main cause of death in these patients is cardiovascular disease (CVD). Novel markers of vascular integrity may thus be of clinical value for identifying patients at high risk for CVD. Here we associated the levels of selected circulating angiogenic miRNAs, angiopoietin-2 (Ang-2) and asymmetric dimethylarginine (ADMA) with cardiovascular structure and function (as determined by cardiovascular MRI) in 67 older patients reaching ESKD that were included from ‘The Cognitive decline in Older Patients with End stage renal disease’ (COPE) prospective, multicentered cohort study. We first determined the association between the vascular injury markers and specific heart conditions and observed that ESKD patients with coronary heart disease have significantly higher levels of circulating ADMA and miR-27a. Moreover, circulating levels of miR-27a were higher in patients with atrial fibrillation. In addition, the circulating levels of the vascular injury markers were associated with measures of cardiovascular structure and function obtained from cardiovascular MRI: pulse wave velocity (PWV), ejection fraction (EF) and cardiac index (CI). We found Ang-2 and miR-27a to be strongly correlated to the PWV, while Ang-2 also associated with ejection fraction. Finally, we observed that in contrast to miR-27a, Ang-2 was not associated with a vascular cause of the primary kidney disease, suggesting Ang-2 may be an ESKD-specific marker of vascular injury. Taken together, among older patients with ESKD, aberrant levels of vascular injury markers (miR-27a, Ang-2 and ADMA) associated with impaired cardiovascular function. These markers may serve to identify individuals at higher risk of CVD, as well as give insight into the underlying (vascular) pathophysiology.
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spelling pubmed-87885432022-01-26 Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease Zhao, Qiao Nooren, Sabine J. L. Zijlstra, Laurien E. Westenberg, Jos J. M. Kroft, Lucia J. M. Jukema, J. Wouter Berkhout-Byrne, Noeleen C. Rabelink, Ton J. van Zonneveld, Anton Jan van Buren, Marjolijn Mooijaart, Simon P. Bijkerk, Roel Noncoding RNA Article The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly occurring in patients aged 65 years or older. The main cause of death in these patients is cardiovascular disease (CVD). Novel markers of vascular integrity may thus be of clinical value for identifying patients at high risk for CVD. Here we associated the levels of selected circulating angiogenic miRNAs, angiopoietin-2 (Ang-2) and asymmetric dimethylarginine (ADMA) with cardiovascular structure and function (as determined by cardiovascular MRI) in 67 older patients reaching ESKD that were included from ‘The Cognitive decline in Older Patients with End stage renal disease’ (COPE) prospective, multicentered cohort study. We first determined the association between the vascular injury markers and specific heart conditions and observed that ESKD patients with coronary heart disease have significantly higher levels of circulating ADMA and miR-27a. Moreover, circulating levels of miR-27a were higher in patients with atrial fibrillation. In addition, the circulating levels of the vascular injury markers were associated with measures of cardiovascular structure and function obtained from cardiovascular MRI: pulse wave velocity (PWV), ejection fraction (EF) and cardiac index (CI). We found Ang-2 and miR-27a to be strongly correlated to the PWV, while Ang-2 also associated with ejection fraction. Finally, we observed that in contrast to miR-27a, Ang-2 was not associated with a vascular cause of the primary kidney disease, suggesting Ang-2 may be an ESKD-specific marker of vascular injury. Taken together, among older patients with ESKD, aberrant levels of vascular injury markers (miR-27a, Ang-2 and ADMA) associated with impaired cardiovascular function. These markers may serve to identify individuals at higher risk of CVD, as well as give insight into the underlying (vascular) pathophysiology. MDPI 2022-01-10 /pmc/articles/PMC8788543/ /pubmed/35076541 http://dx.doi.org/10.3390/ncrna8010002 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Qiao
Nooren, Sabine J. L.
Zijlstra, Laurien E.
Westenberg, Jos J. M.
Kroft, Lucia J. M.
Jukema, J. Wouter
Berkhout-Byrne, Noeleen C.
Rabelink, Ton J.
van Zonneveld, Anton Jan
van Buren, Marjolijn
Mooijaart, Simon P.
Bijkerk, Roel
Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease
title Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease
title_full Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease
title_fullStr Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease
title_full_unstemmed Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease
title_short Circulating miRNAs and Vascular Injury Markers Associate with Cardiovascular Function in Older Patients Reaching End-Stage Kidney Disease
title_sort circulating mirnas and vascular injury markers associate with cardiovascular function in older patients reaching end-stage kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788543/
https://www.ncbi.nlm.nih.gov/pubmed/35076541
http://dx.doi.org/10.3390/ncrna8010002
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