Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC

RNA interference (RNAi) molecules have tremendous potential for cancer therapy but are limited by insufficient potency after intravenous (IV) administration. We previously found that polymer complexes (polyplexes) formed between 3′-cholesterol-modified siRNA (Chol-siRNA) or DsiRNA (Chol-DsiRNA) and...

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Detalles Bibliográficos
Autores principales: Ye, Zhen, Abdelmoaty, Mai Mohamed, Curran, Stephen M., Dyavar, Shetty Ravi, Kumar, Devendra, Alnouti, Yazen, Coulter, Don W., Podany, Anthony T., Singh, Rakesh K., Vetro, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788547/
https://www.ncbi.nlm.nih.gov/pubmed/35076584
http://dx.doi.org/10.3390/ncrna8010008

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