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Hypomyelinating Leukodystrophy 7 (HLD7)-Associated Mutation of POLR3A Is Related to Defective Oligodendroglial Cell Differentiation, Which Is Ameliorated by Ibuprofen

Hypomyelinating leukodystrophy 7 (HLD7) is an autosomal recessive oligodendroglial cell-related myelin disease, which is associated with some nucleotide mutations of the RNA polymerase 3 subunit a (polr3a) gene. POLR3A is composed of the catalytic core of RNA polymerase III synthesizing non-coding R...

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Detalles Bibliográficos
Autores principales:	Sawaguchi, Sui, Tago, Kenji, Oizumi, Hiroaki, Ohbuchi, Katsuya, Yamamoto, Masahiro, Mizoguchi, Kazushige, Miyamoto, Yuki, Yamauchi, Junji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788570/ https://www.ncbi.nlm.nih.gov/pubmed/35076634 http://dx.doi.org/10.3390/neurolint14010002

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