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Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China

Chlamydia trachomatis (CT) infection is the most prevalent sexually transmitted bacterial disease worldwide. However, unlike that in female infertility, the role of CT infection in male infertility remains controversial. The objective of this retrospective study was to explore the impacts of CT infe...

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Autores principales: Zhou, Hua, Wu, Shunhong, Tang, Xiaohua, Zhou, Guanqing, Yuan, Jingru, Li, Qing, Chen, Yaoyong, Xu, Xia, Sun, Xiaofang, Zhu, Detu, Luo, Yumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788609/
https://www.ncbi.nlm.nih.gov/pubmed/34145079
http://dx.doi.org/10.4103/aja.aja_54_21
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author Zhou, Hua
Wu, Shunhong
Tang, Xiaohua
Zhou, Guanqing
Yuan, Jingru
Li, Qing
Chen, Yaoyong
Xu, Xia
Sun, Xiaofang
Zhu, Detu
Luo, Yumei
author_facet Zhou, Hua
Wu, Shunhong
Tang, Xiaohua
Zhou, Guanqing
Yuan, Jingru
Li, Qing
Chen, Yaoyong
Xu, Xia
Sun, Xiaofang
Zhu, Detu
Luo, Yumei
author_sort Zhou, Hua
collection PubMed
description Chlamydia trachomatis (CT) infection is the most prevalent sexually transmitted bacterial disease worldwide. However, unlike that in female infertility, the role of CT infection in male infertility remains controversial. The objective of this retrospective study was to explore the impacts of CT infection in the genital tract on sperm quality, sperm acrosin activity, antisperm antibody levels, and inflammation in a large cohort of infertile males in China. A total of 7154 semen samples were collected from infertile male subjects, 416 of whom were CT positive (CT+ group) and 6738 of whom were CT negative (CT− group), in our hospital between January 2016 and December 2018. Routine semen parameters (semen volume, pH, sperm concentration, viability, motility, morphology, etc.), granulocyte elastase levels, antisperm antibody levels, and sperm acrosin activity were compared between the CT+ and CT− groups. Our results showed that CT infection was significantly correlated with an abnormally low semen volume, as well as an increased white blood cell count and granulocyte elastase level (all P < 0.05) in the semen of infertile males; other routine semen parameters were not negatively impacted. The antisperm antibody level and sperm acrosin activity were not affected by CT infection. These findings suggested that CT infection might contribute to inflammation and hypospermia but does not impair sperm viability, motility morphology, and acrosin activity or generate antisperm antibodies in the infertile males of China.
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spelling pubmed-87886092022-02-03 Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China Zhou, Hua Wu, Shunhong Tang, Xiaohua Zhou, Guanqing Yuan, Jingru Li, Qing Chen, Yaoyong Xu, Xia Sun, Xiaofang Zhu, Detu Luo, Yumei Asian J Androl Original Article Chlamydia trachomatis (CT) infection is the most prevalent sexually transmitted bacterial disease worldwide. However, unlike that in female infertility, the role of CT infection in male infertility remains controversial. The objective of this retrospective study was to explore the impacts of CT infection in the genital tract on sperm quality, sperm acrosin activity, antisperm antibody levels, and inflammation in a large cohort of infertile males in China. A total of 7154 semen samples were collected from infertile male subjects, 416 of whom were CT positive (CT+ group) and 6738 of whom were CT negative (CT− group), in our hospital between January 2016 and December 2018. Routine semen parameters (semen volume, pH, sperm concentration, viability, motility, morphology, etc.), granulocyte elastase levels, antisperm antibody levels, and sperm acrosin activity were compared between the CT+ and CT− groups. Our results showed that CT infection was significantly correlated with an abnormally low semen volume, as well as an increased white blood cell count and granulocyte elastase level (all P < 0.05) in the semen of infertile males; other routine semen parameters were not negatively impacted. The antisperm antibody level and sperm acrosin activity were not affected by CT infection. These findings suggested that CT infection might contribute to inflammation and hypospermia but does not impair sperm viability, motility morphology, and acrosin activity or generate antisperm antibodies in the infertile males of China. Wolters Kluwer - Medknow 2021-06-18 /pmc/articles/PMC8788609/ /pubmed/34145079 http://dx.doi.org/10.4103/aja.aja_54_21 Text en Copyright: ©The Author(s)(2021) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Zhou, Hua
Wu, Shunhong
Tang, Xiaohua
Zhou, Guanqing
Yuan, Jingru
Li, Qing
Chen, Yaoyong
Xu, Xia
Sun, Xiaofang
Zhu, Detu
Luo, Yumei
Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
title Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
title_full Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
title_fullStr Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
title_full_unstemmed Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
title_short Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China
title_sort chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788609/
https://www.ncbi.nlm.nih.gov/pubmed/34145079
http://dx.doi.org/10.4103/aja.aja_54_21
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