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Contribution of Postjunctional M2 Muscarinic Receptors to Cholinergic Nerve-Mediated Contractions of Murine Airway Smooth Muscle

Postjunctional M2Rs on airway smooth muscle (ASM) outnumber M3Rs by a ratio of 4:1 in most species, however, it is the M3Rs that are thought to mediate the bronchoconstrictor effects of acetylcholine. In this study, we describe a novel and profound M2R-mediated hypersensitization of M3R-dependent co...

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Detalles Bibliográficos
Autores principales:	Alkawadri, Tuleen, McGarvey, Lorcan P, Mullins, N D, Hollywood, Mark A, Thornbury, Keith D, Sergeant, Gerard P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788713/ https://www.ncbi.nlm.nih.gov/pubmed/35330928 http://dx.doi.org/10.1093/function/zqab053

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