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Therapeutic potential of pyrrole and pyrrolidine analogs: an update
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788913/ https://www.ncbi.nlm.nih.gov/pubmed/35079946 http://dx.doi.org/10.1007/s11030-022-10387-8 |
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author | Jeelan Basha, N. Basavarajaiah, S. M. Shyamsunder, K. |
author_facet | Jeelan Basha, N. Basavarajaiah, S. M. Shyamsunder, K. |
author_sort | Jeelan Basha, N. |
collection | PubMed |
description | The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-8788913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-87889132022-01-25 Therapeutic potential of pyrrole and pyrrolidine analogs: an update Jeelan Basha, N. Basavarajaiah, S. M. Shyamsunder, K. Mol Divers Comprehensive Review The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2022-01-25 2022 /pmc/articles/PMC8788913/ /pubmed/35079946 http://dx.doi.org/10.1007/s11030-022-10387-8 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Comprehensive Review Jeelan Basha, N. Basavarajaiah, S. M. Shyamsunder, K. Therapeutic potential of pyrrole and pyrrolidine analogs: an update |
title | Therapeutic potential of pyrrole and pyrrolidine analogs: an update |
title_full | Therapeutic potential of pyrrole and pyrrolidine analogs: an update |
title_fullStr | Therapeutic potential of pyrrole and pyrrolidine analogs: an update |
title_full_unstemmed | Therapeutic potential of pyrrole and pyrrolidine analogs: an update |
title_short | Therapeutic potential of pyrrole and pyrrolidine analogs: an update |
title_sort | therapeutic potential of pyrrole and pyrrolidine analogs: an update |
topic | Comprehensive Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788913/ https://www.ncbi.nlm.nih.gov/pubmed/35079946 http://dx.doi.org/10.1007/s11030-022-10387-8 |
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