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Therapeutic potential of pyrrole and pyrrolidine analogs: an update

The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes...

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Detalles Bibliográficos
Autores principales: Jeelan Basha, N., Basavarajaiah, S. M., Shyamsunder, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788913/
https://www.ncbi.nlm.nih.gov/pubmed/35079946
http://dx.doi.org/10.1007/s11030-022-10387-8
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author Jeelan Basha, N.
Basavarajaiah, S. M.
Shyamsunder, K.
author_facet Jeelan Basha, N.
Basavarajaiah, S. M.
Shyamsunder, K.
author_sort Jeelan Basha, N.
collection PubMed
description The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-87889132022-01-25 Therapeutic potential of pyrrole and pyrrolidine analogs: an update Jeelan Basha, N. Basavarajaiah, S. M. Shyamsunder, K. Mol Divers Comprehensive Review The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2022-01-25 2022 /pmc/articles/PMC8788913/ /pubmed/35079946 http://dx.doi.org/10.1007/s11030-022-10387-8 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comprehensive Review
Jeelan Basha, N.
Basavarajaiah, S. M.
Shyamsunder, K.
Therapeutic potential of pyrrole and pyrrolidine analogs: an update
title Therapeutic potential of pyrrole and pyrrolidine analogs: an update
title_full Therapeutic potential of pyrrole and pyrrolidine analogs: an update
title_fullStr Therapeutic potential of pyrrole and pyrrolidine analogs: an update
title_full_unstemmed Therapeutic potential of pyrrole and pyrrolidine analogs: an update
title_short Therapeutic potential of pyrrole and pyrrolidine analogs: an update
title_sort therapeutic potential of pyrrole and pyrrolidine analogs: an update
topic Comprehensive Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788913/
https://www.ncbi.nlm.nih.gov/pubmed/35079946
http://dx.doi.org/10.1007/s11030-022-10387-8
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