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The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens

The study aimed to examine the effect of simultaneous application of florfenicol and lasalocid on the performance and vital organ function of chickens. For this, 300 chicks were divided into four groups. Group one to three received florfenicol, lasalocid and lasalocid plus florfenicol, respectively....

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Autores principales: Gholami‐Ahangaran, Majid, Karimi‐Dehkordi, Maryam, Namjoo, Abdolrasul, Shojaei, Hasan, Ahmadi‐Dastgerdi, Asiye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788961/
https://www.ncbi.nlm.nih.gov/pubmed/34498431
http://dx.doi.org/10.1002/vms3.626
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author Gholami‐Ahangaran, Majid
Karimi‐Dehkordi, Maryam
Namjoo, Abdolrasul
Shojaei, Hasan
Ahmadi‐Dastgerdi, Asiye
author_facet Gholami‐Ahangaran, Majid
Karimi‐Dehkordi, Maryam
Namjoo, Abdolrasul
Shojaei, Hasan
Ahmadi‐Dastgerdi, Asiye
author_sort Gholami‐Ahangaran, Majid
collection PubMed
description The study aimed to examine the effect of simultaneous application of florfenicol and lasalocid on the performance and vital organ function of chickens. For this, 300 chicks were divided into four groups. Group one to three received florfenicol, lasalocid and lasalocid plus florfenicol, respectively. Group four as the control group received a basic diet without lasalocid or florfenicol. Lasalocid was used from 7 to 35 days old, continuously. Florfenicol was used at 21 days old for 5 days. The growth indices were measured at the end of each week. The chickens were euthanized at the ages of 28 and 35 days old after collecting blood samples with and without anticoagulants. The liver, heart, muscle, kidney and sciatic nerve were collected in formalin 10% for histopathological examination. The blood and serum samples were used to determine clinical pathologic and hematologic indices. The ratio of internal organs to body weight and ratio of the right ventricle to the total ventricles (RV/TV) of the heart was measured. Results showed, the use of lasalocid decreased feed conversion rate and triglyceride, and increased total protein. Simultaneous administration of lasalocid and florfenicol affected histopathology of the liver and heart and significantly increased creatine phosphokinase, uric acid and the ratio of RV/TV of heart. The eosinophil percentage in the chickens who received florfenicol plus lasalocid was significantly higher than chickens who received florfenicol alone (p < 0.05). In conclusion, it seems that simultaneous administration of the florfenicol and lasalocid induces side‐effects especially on cardiac function and it is not recommended.
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spelling pubmed-87889612022-02-01 The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens Gholami‐Ahangaran, Majid Karimi‐Dehkordi, Maryam Namjoo, Abdolrasul Shojaei, Hasan Ahmadi‐Dastgerdi, Asiye Vet Med Sci POULTRY The study aimed to examine the effect of simultaneous application of florfenicol and lasalocid on the performance and vital organ function of chickens. For this, 300 chicks were divided into four groups. Group one to three received florfenicol, lasalocid and lasalocid plus florfenicol, respectively. Group four as the control group received a basic diet without lasalocid or florfenicol. Lasalocid was used from 7 to 35 days old, continuously. Florfenicol was used at 21 days old for 5 days. The growth indices were measured at the end of each week. The chickens were euthanized at the ages of 28 and 35 days old after collecting blood samples with and without anticoagulants. The liver, heart, muscle, kidney and sciatic nerve were collected in formalin 10% for histopathological examination. The blood and serum samples were used to determine clinical pathologic and hematologic indices. The ratio of internal organs to body weight and ratio of the right ventricle to the total ventricles (RV/TV) of the heart was measured. Results showed, the use of lasalocid decreased feed conversion rate and triglyceride, and increased total protein. Simultaneous administration of lasalocid and florfenicol affected histopathology of the liver and heart and significantly increased creatine phosphokinase, uric acid and the ratio of RV/TV of heart. The eosinophil percentage in the chickens who received florfenicol plus lasalocid was significantly higher than chickens who received florfenicol alone (p < 0.05). In conclusion, it seems that simultaneous administration of the florfenicol and lasalocid induces side‐effects especially on cardiac function and it is not recommended. John Wiley and Sons Inc. 2021-09-08 /pmc/articles/PMC8788961/ /pubmed/34498431 http://dx.doi.org/10.1002/vms3.626 Text en © 2021 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle POULTRY
Gholami‐Ahangaran, Majid
Karimi‐Dehkordi, Maryam
Namjoo, Abdolrasul
Shojaei, Hasan
Ahmadi‐Dastgerdi, Asiye
The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
title The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
title_full The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
title_fullStr The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
title_full_unstemmed The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
title_short The co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
title_sort co‐administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens
topic POULTRY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788961/
https://www.ncbi.nlm.nih.gov/pubmed/34498431
http://dx.doi.org/10.1002/vms3.626
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