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Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China

We aimed to assess the association between fasting plasma glucose (FPG) change trajectory and incident hypertension among Chinese population. This cohort study included 11,791 adults aged 18–80 years without hypertension at first entry and who completed at least four follow-ups between 2009 and 2016...

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Autores principales: Lou, Yanmei, Zhang, Yanyan, Zhao, Ping, Qin, Pei, Wang, Changyi, Ma, Jianping, Peng, Xiaolin, Chen, Hongen, Zhao, Dan, Xu, Shan, Wang, Li, Zhang, Ming, Hu, Dongsheng, Hu, Fulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789013/
https://www.ncbi.nlm.nih.gov/pubmed/34860174
http://dx.doi.org/10.1530/EC-21-0464
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author Lou, Yanmei
Zhang, Yanyan
Zhao, Ping
Qin, Pei
Wang, Changyi
Ma, Jianping
Peng, Xiaolin
Chen, Hongen
Zhao, Dan
Xu, Shan
Wang, Li
Zhang, Ming
Hu, Dongsheng
Hu, Fulan
author_facet Lou, Yanmei
Zhang, Yanyan
Zhao, Ping
Qin, Pei
Wang, Changyi
Ma, Jianping
Peng, Xiaolin
Chen, Hongen
Zhao, Dan
Xu, Shan
Wang, Li
Zhang, Ming
Hu, Dongsheng
Hu, Fulan
author_sort Lou, Yanmei
collection PubMed
description We aimed to assess the association between fasting plasma glucose (FPG) change trajectory and incident hypertension among Chinese population. This cohort study included 11,791 adults aged 18–80 years without hypertension at first entry and who completed at least four follow-ups between 2009 and 2016. Logistic regression was used to estimate odds ratios (ORs) and 95% CIs for the association between FPG change trajectory and probability of hypertension. During a median follow-up of 5.10 years (total person–years 61,887.76), hypertension developed in 2177 participants. After adjusting for baseline potential confounders, the probability of hypertension increased with the increasing FPG change trajectory (adjusted OR (aOR) 1.22, 95% CI 1.07–1.40), bell-shape trajectory (aOR 1.15, 95% CI 1.02–1.30) and other-shape trajectory (aOR 1.13, 95% CI 1.02–1.25) which showed a higher variability of FPG compared to the decreasing group. In addition, the increasing FPG change trajectory was associated with a higher probability of hypertension compared with the decreasing group regardless of age and BMI but was only significant in males and in those with normal FPG at baseline. Our study indicates that the increasing FPG change trajectory determines the highest risk of hypertension, demonstrating the importance of maintaining low and stable levels of FPG, especially in males and in those with normal FPG.
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spelling pubmed-87890132022-01-28 Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China Lou, Yanmei Zhang, Yanyan Zhao, Ping Qin, Pei Wang, Changyi Ma, Jianping Peng, Xiaolin Chen, Hongen Zhao, Dan Xu, Shan Wang, Li Zhang, Ming Hu, Dongsheng Hu, Fulan Endocr Connect Research We aimed to assess the association between fasting plasma glucose (FPG) change trajectory and incident hypertension among Chinese population. This cohort study included 11,791 adults aged 18–80 years without hypertension at first entry and who completed at least four follow-ups between 2009 and 2016. Logistic regression was used to estimate odds ratios (ORs) and 95% CIs for the association between FPG change trajectory and probability of hypertension. During a median follow-up of 5.10 years (total person–years 61,887.76), hypertension developed in 2177 participants. After adjusting for baseline potential confounders, the probability of hypertension increased with the increasing FPG change trajectory (adjusted OR (aOR) 1.22, 95% CI 1.07–1.40), bell-shape trajectory (aOR 1.15, 95% CI 1.02–1.30) and other-shape trajectory (aOR 1.13, 95% CI 1.02–1.25) which showed a higher variability of FPG compared to the decreasing group. In addition, the increasing FPG change trajectory was associated with a higher probability of hypertension compared with the decreasing group regardless of age and BMI but was only significant in males and in those with normal FPG at baseline. Our study indicates that the increasing FPG change trajectory determines the highest risk of hypertension, demonstrating the importance of maintaining low and stable levels of FPG, especially in males and in those with normal FPG. Bioscientifica Ltd 2021-12-03 /pmc/articles/PMC8789013/ /pubmed/34860174 http://dx.doi.org/10.1530/EC-21-0464 Text en © The authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research
Lou, Yanmei
Zhang, Yanyan
Zhao, Ping
Qin, Pei
Wang, Changyi
Ma, Jianping
Peng, Xiaolin
Chen, Hongen
Zhao, Dan
Xu, Shan
Wang, Li
Zhang, Ming
Hu, Dongsheng
Hu, Fulan
Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China
title Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China
title_full Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China
title_fullStr Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China
title_full_unstemmed Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China
title_short Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China
title_sort association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789013/
https://www.ncbi.nlm.nih.gov/pubmed/34860174
http://dx.doi.org/10.1530/EC-21-0464
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