Cargando…

Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p

The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of the coronavirus life cycle. The causative agent of the disease, SARS-CoV-2, is being studied extensively from a structural standpoint in order to gain insight into key molecular mechanisms required for its...

Descripción completa

Detalles Bibliográficos
Autores principales:	Imperatore, Joshua A, Cunningham, Caylee L, Pellegrene, Kendy A, Brinson, Robert G, Marino, John P, Evanseck, Jeffrey D, Mihailescu, Mihaela Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789046/ https://www.ncbi.nlm.nih.gov/pubmed/34908151 http://dx.doi.org/10.1093/nar/gkab1226

Ejemplares similares

Conserved Elements in the 3'-UTR of SARS-CoV-2: Involvement in Genomic Dimerization and Interactions with Cellular Micrornas
por: Imperatore, Joshua A., et al.
Publicado: (2021)

PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2)
por: Landry-Voyer, Anne-Marie, et al.
Publicado: (2020)

Dimerization of an umbravirus RNA genome activates subgenomic mRNA transcription
por: Chkuaseli, Tamari, et al.
Publicado: (2023)

Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA
por: Matsuoka, Tatsuya, et al.
Publicado: (2018)

Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem
por: Zhu, Li, et al.
Publicado: (2018)

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors
por: Müller, Simon, et al.
Publicado: (2018)

IGF2BP1 promotes SRF-dependent transcription in cancer in a m(6)A- and miRNA-dependent manner
por: Müller, Simon, et al.
Publicado: (2019)

Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs
por: Tosar, Juan Pablo, et al.
Publicado: (2018)

LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection
por: Takahashi, Tomoko, et al.
Publicado: (2020)

Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2
por: Sherpa, Chringma, et al.
Publicado: (2018)

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer
por: Gupta, Kushol, et al.
Publicado: (2021)

A novel role for gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors
por: Vamva, Eirini, et al.
Publicado: (2021)

NF90 modulates processing of a subset of human pri-miRNAs
por: Grasso, Giuseppa, et al.
Publicado: (2020)

Insights into the evolutionary conserved regulation of Rio ATPase activity
por: Knüppel, Robert, et al.
Publicado: (2018)

PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing
por: Rajasekaran, Swetha, et al.
Publicado: (2022)

Characterization of SARS-CoV-2 Conserved Elements’ Structures and their RNA-RNA Interactions
por: Cunningham, Caylee, et al.
Publicado: (2021)

Identification of conserved, primary sequence motifs that direct retrovirus RNA fate
por: Singh, Gatikrushna, et al.
Publicado: (2018)

Identification of new high affinity targets for Roquin based on structural conservation
por: Braun, Johannes, et al.
Publicado: (2018)

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells
por: Ouyang, Huiwu, et al.
Publicado: (2017)

SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis
por: Bajczyk, Mateusz, et al.
Publicado: (2020)

Structural basis of successive adenosine modifications by the conserved ribosomal methyltransferase KsgA
por: Stephan, Niklas C, et al.
Publicado: (2021)

A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5′ splice site identity
por: Cartwright-Acar, Catiana H, et al.
Publicado: (2022)

Computational analysis of ribonomics datasets identifies long non-coding RNA targets of γ-herpesviral miRNAs
por: Sethuraman, Sunantha, et al.
Publicado: (2018)

Eukaryotic tRNA sequences present conserved and amino acid-specific structural signatures
por: Westhof, Eric, et al.
Publicado: (2022)

The low-resolution structural models of hepatitis C virus RNA subdomain 5BSL3.2 and its distal complex with domain 3′X point to conserved regulatory mechanisms within the Flaviviridae family
por: Castillo-Martínez, Jesús, et al.
Publicado: (2022)

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA
por: de Regt, Ann Kristin, et al.
Publicado: (2023)

SMA1, a homolog of the splicing factor Prp28, has a multifaceted role in miRNA biogenesis in Arabidopsis
por: Li, Shengjun, et al.
Publicado: (2018)

DAZL regulates proliferation of human primordial germ cells by direct binding to precursor miRNAs and enhances DICER processing activity
por: Yan, An, et al.
Publicado: (2022)

Conserved structures formed by heterogeneous RNA sequences drive silencing of an inflammation responsive post-transcriptional operon
por: Basu, Abhijit, et al.
Publicado: (2017)

A conserved RNA structure is essential for a satellite RNA-mediated inhibition of helper virus accumulation
por: He, Lu, et al.
Publicado: (2019)

AGO-unbound cytosolic pool of mature miRNAs in plant cells reveals a novel regulatory step at AGO1 loading
por: Dalmadi, Ágnes, et al.
Publicado: (2019)

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition
por: Tunnicliffe, Richard B, et al.
Publicado: (2019)

G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA
por: Simko, Eric A J, et al.
Publicado: (2020)

The conserved 3′ UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration
por: Wang, Chuan, et al.
Publicado: (2020)

The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex
por: Yeh, Chung-Shu, et al.
Publicado: (2017)

The human box C/D snoRNA U3 is a miRNA source and miR-U3 regulates expression of sortin nexin 27
por: Lemus-Diaz, Nicolas, et al.
Publicado: (2020)

Identification of clustered organellar short (cos) RNAs and of a conserved family of organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in the malaria parasite
por: Hillebrand, Arne, et al.
Publicado: (2018)

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin
por: Tanaka, Iris, et al.
Publicado: (2020)

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017)

Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection
por: Khoury, Georges, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kfkvreif6iksncjkl4nakk76gh