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Regulation of AR mRNA translation in response to acute AR pathway inhibition

We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection in response to AR pathway inhibition (ARPI) stress in prostate cancer (PCA). AR mRNA translation is coordinately regulated by RNA binding proteins, YTHDF3 and G3BP1. Under ambient conditions m6A-modified AR mRNA i...

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Detalles Bibliográficos
Autores principales:	Somasekharan, Syam Prakash, Saxena, Neetu, Zhang, Fan, Beraldi, Eliana, Huang, Jia Ni, Gentle, Christina, Fazli, Ladan, Thi, Marisa, Sorensen, Poul H, Gleave, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789049/ https://www.ncbi.nlm.nih.gov/pubmed/34939643 http://dx.doi.org/10.1093/nar/gkab1247

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