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Pairing of single mutations yields obligate Cre-type site-specific recombinases

Tyrosine site-specific recombinases (SSRs) represent a versatile genome editing tool with considerable therapeutic potential. Recent developments to engineer and evolve SSRs into heterotetramers to improve target site flexibility signified a critical step towards their broad utility in genome editin...

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Detalles Bibliográficos
Autores principales:	Hoersten, Jenna, Ruiz-Gómez, Gloria, Lansing, Felix, Rojo-Romanos, Teresa, Schmitt, Lukas Theo, Sonntag, Jan, Pisabarro, M Teresa, Buchholz, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789052/ https://www.ncbi.nlm.nih.gov/pubmed/34951450 http://dx.doi.org/10.1093/nar/gkab1240

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