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Redirecting meiotic DNA break hotspot determinant proteins alters localized spatial control of DNA break formation and repair

During meiosis, DNA double-strand breaks (DSBs) are formed at high frequency at special chromosomal sites, called DSB hotspots, to generate crossovers that aid proper chromosome segregation. Multiple chromosomal features affect hotspot formation. In the fission yeast S. pombe the linear element prot...

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Detalles Bibliográficos
Autores principales:	Hyppa, Randy W, Cho, Joshua D, Nambiar, Mridula, Smith, Gerald R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789058/ https://www.ncbi.nlm.nih.gov/pubmed/34967417 http://dx.doi.org/10.1093/nar/gkab1253

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