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Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne pathogens that can cause arthritis or encephalitis diseases. Nonstructural protein 4 (nsP4) of alphaviruses possesses RNA-dependent RNA pol...

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Detalles Bibliográficos
Autores principales:	Tan, Yaw Bia, Lello, Laura Sandra, Liu, Xin, Law, Yee-Song, Kang, Congbao, Lescar, Julien, Zheng, Jie, Merits, Andres, Luo, Dahai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789068/ https://www.ncbi.nlm.nih.gov/pubmed/35037043 http://dx.doi.org/10.1093/nar/gkab1302

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