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Structure–activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB

Mycobacterial AdnAB is a heterodimeric helicase-nuclease that initiates homologous recombination by resecting DNA double-strand breaks. The AdnB subunit hydrolyzes ATP to drive single-nucleotide steps of 3′-to-5′ translocation of AdnAB on the tracking DNA strand via a ratchet-like mechanism. Trp325...

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Detalles Bibliográficos
Autores principales:	Warren, Garrett M, Meir, Aviv, Wang, Juncheng, Patel, Dinshaw J, Greene, Eric C, Shuman, Stewart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789073/ https://www.ncbi.nlm.nih.gov/pubmed/34967418 http://dx.doi.org/10.1093/nar/gkab1270

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