Condensin extrudes DNA loops in steps up to hundreds of base pairs that are generated by ATP binding events

The condensin SMC protein complex organizes chromosomal structure by extruding loops of DNA. Its ATP-dependent motor mechanism remains unclear but likely involves steps associated with large conformational changes within the ∼50 nm protein complex. Here, using high-resolution magnetic tweezers, we r...

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Detalles Bibliográficos
Autores principales: Ryu, Je-Kyung, Rah, Sang-Hyun, Janissen, Richard, Kerssemakers, Jacob W J, Bonato, Andrea, Michieletto, Davide, Dekker, Cees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789078/
https://www.ncbi.nlm.nih.gov/pubmed/34951453
http://dx.doi.org/10.1093/nar/gkab1268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789078/
https://www.ncbi.nlm.nih.gov/pubmed/34951453
http://dx.doi.org/10.1093/nar/gkab1268

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