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Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia

Cambodia has one of the highest dengue infection rates in Southeast Asia. Here we report quantitative entomological results of a large-scale cluster-randomised trial assessing the impact on vector populations of a package of vector control interventions including larvivorous guppy fish in household...

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Detalles Bibliográficos
Autores principales: Bigio, Jacob, Braack, Leo, Chea, Thy, Set, Srun, Suon, Sokha, Echaubard, Pierre, Hustedt, John, Debackere, Mark, Ramirez, Bernadette, Prasetyo, Didot Budi, Bunleng, Sam, Wharton-Smith, Alexandra, Hii, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789142/
https://www.ncbi.nlm.nih.gov/pubmed/35077452
http://dx.doi.org/10.1371/journal.pntd.0010028
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author Bigio, Jacob
Braack, Leo
Chea, Thy
Set, Srun
Suon, Sokha
Echaubard, Pierre
Hustedt, John
Debackere, Mark
Ramirez, Bernadette
Prasetyo, Didot Budi
Bunleng, Sam
Wharton-Smith, Alexandra
Hii, Jeffrey
author_facet Bigio, Jacob
Braack, Leo
Chea, Thy
Set, Srun
Suon, Sokha
Echaubard, Pierre
Hustedt, John
Debackere, Mark
Ramirez, Bernadette
Prasetyo, Didot Budi
Bunleng, Sam
Wharton-Smith, Alexandra
Hii, Jeffrey
author_sort Bigio, Jacob
collection PubMed
description Cambodia has one of the highest dengue infection rates in Southeast Asia. Here we report quantitative entomological results of a large-scale cluster-randomised trial assessing the impact on vector populations of a package of vector control interventions including larvivorous guppy fish in household water containers, mosquito trapping with gravid-ovitraps, solid waste management, breeding-container coverage through community education and engagement for behavioural change, particularly through the participation of school children. These activities resulted in major reductions in Container Index, House Index, Breteau Index, Pupal Index and Adult Index (all p-values 0.002 or lower) in the Intervention Arm compared with the Control Arm in a series of household surveys conducted over a follow-up period of more than one year, although the project was not able to measure the longer-term sustainability of the interventions. Despite comparative reductions in Adult Index between the study arms, the Adult Index was higher in the Intervention Arm in the final household survey than in the first household survey. This package of biophysical and community engagement interventions was highly effective in reducing entomological indices for dengue compared with the control group, but caution is required in extrapolating the reduction in household Adult Index to a reduction in the overall population of adult Aedes mosquitoes, and in interpreting the relationship between a reduction in entomological indices and a reduction in the number of dengue cases. The package of interventions should be trialled in other locations.
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spelling pubmed-87891422022-01-26 Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia Bigio, Jacob Braack, Leo Chea, Thy Set, Srun Suon, Sokha Echaubard, Pierre Hustedt, John Debackere, Mark Ramirez, Bernadette Prasetyo, Didot Budi Bunleng, Sam Wharton-Smith, Alexandra Hii, Jeffrey PLoS Negl Trop Dis Research Article Cambodia has one of the highest dengue infection rates in Southeast Asia. Here we report quantitative entomological results of a large-scale cluster-randomised trial assessing the impact on vector populations of a package of vector control interventions including larvivorous guppy fish in household water containers, mosquito trapping with gravid-ovitraps, solid waste management, breeding-container coverage through community education and engagement for behavioural change, particularly through the participation of school children. These activities resulted in major reductions in Container Index, House Index, Breteau Index, Pupal Index and Adult Index (all p-values 0.002 or lower) in the Intervention Arm compared with the Control Arm in a series of household surveys conducted over a follow-up period of more than one year, although the project was not able to measure the longer-term sustainability of the interventions. Despite comparative reductions in Adult Index between the study arms, the Adult Index was higher in the Intervention Arm in the final household survey than in the first household survey. This package of biophysical and community engagement interventions was highly effective in reducing entomological indices for dengue compared with the control group, but caution is required in extrapolating the reduction in household Adult Index to a reduction in the overall population of adult Aedes mosquitoes, and in interpreting the relationship between a reduction in entomological indices and a reduction in the number of dengue cases. The package of interventions should be trialled in other locations. Public Library of Science 2022-01-25 /pmc/articles/PMC8789142/ /pubmed/35077452 http://dx.doi.org/10.1371/journal.pntd.0010028 Text en © 2022 Bigio et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bigio, Jacob
Braack, Leo
Chea, Thy
Set, Srun
Suon, Sokha
Echaubard, Pierre
Hustedt, John
Debackere, Mark
Ramirez, Bernadette
Prasetyo, Didot Budi
Bunleng, Sam
Wharton-Smith, Alexandra
Hii, Jeffrey
Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia
title Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia
title_full Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia
title_fullStr Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia
title_full_unstemmed Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia
title_short Entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in Kampong Cham province, Cambodia
title_sort entomological outcomes of cluster-randomised, community-driven dengue vector-suppression interventions in kampong cham province, cambodia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789142/
https://www.ncbi.nlm.nih.gov/pubmed/35077452
http://dx.doi.org/10.1371/journal.pntd.0010028
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