P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss

Progressive immune deficiency of aging is characterized by severe thymic atrophy, contracted T cell repertoire, and poor immune function. p63 is critical for the proliferative potential of embryonic and adult stem cells, as well as thymic epithelial cells (TECs). Because p63 null mice experience rap...

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Detalles Bibliográficos
Autores principales: Stefanski, Heather E., Xing, Yan, Nicholls, Jemma, Jonart, Leslie, Goren, Emily, Taylor, Patricia A., Mills, Alea A., Riddle, Megan, McGrath, John, Tolar, Jakub, Hollander, Georg A., Blazar, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789144/
https://www.ncbi.nlm.nih.gov/pubmed/35077450
http://dx.doi.org/10.1371/journal.pone.0261770

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