WASP stings into matrix to lead immune cell migration

WASP is a remodeler of the actin cytoskeleton, but its mechanistic contribution to neutrophil migration is unclear. In this issue, Brunetti et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202104046) show that WASP is recruited to substrate-induced membrane deformations near the cell front, w...

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Detalles Bibliográficos
Autores principales: Rottner, Klemens, Stradal, Theresia E.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789199/
https://www.ncbi.nlm.nih.gov/pubmed/35061007
http://dx.doi.org/10.1083/jcb.202112087
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author Rottner, Klemens
Stradal, Theresia E.B.
author_facet Rottner, Klemens
Stradal, Theresia E.B.
author_sort Rottner, Klemens
collection PubMed
description WASP is a remodeler of the actin cytoskeleton, but its mechanistic contribution to neutrophil migration is unclear. In this issue, Brunetti et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202104046) show that WASP is recruited to substrate-induced membrane deformations near the cell front, where it induces Arp2/3 complex–mediated local actin assembly to direct migration.
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spelling pubmed-87891992022-07-21 WASP stings into matrix to lead immune cell migration Rottner, Klemens Stradal, Theresia E.B. J Cell Biol Spotlight WASP is a remodeler of the actin cytoskeleton, but its mechanistic contribution to neutrophil migration is unclear. In this issue, Brunetti et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202104046) show that WASP is recruited to substrate-induced membrane deformations near the cell front, where it induces Arp2/3 complex–mediated local actin assembly to direct migration. Rockefeller University Press 2022-01-21 /pmc/articles/PMC8789199/ /pubmed/35061007 http://dx.doi.org/10.1083/jcb.202112087 Text en © 2022 Rottner and Stradal https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Rottner, Klemens
Stradal, Theresia E.B.
WASP stings into matrix to lead immune cell migration
title WASP stings into matrix to lead immune cell migration
title_full WASP stings into matrix to lead immune cell migration
title_fullStr WASP stings into matrix to lead immune cell migration
title_full_unstemmed WASP stings into matrix to lead immune cell migration
title_short WASP stings into matrix to lead immune cell migration
title_sort wasp stings into matrix to lead immune cell migration
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789199/
https://www.ncbi.nlm.nih.gov/pubmed/35061007
http://dx.doi.org/10.1083/jcb.202112087
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