Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models

Dysregulated homeostasis of neural activity has been hypothesized to drive Alzheimer’s disease (AD) pathogenesis. AD begins with a decades-long presymptomatic phase, but whether homeostatic mechanisms already begin failing during this silent phase is unknown. We show that before the onset of memory...

Descripción completa

Detalles Bibliográficos
Autores principales: Zarhin, Daniel, Atsmon, Refaela, Ruggiero, Antonella, Baeloha, Halit, Shoob, Shiri, Scharf, Oded, Heim, Leore R., Buchbinder, Nadav, Shinikamin, Ortal, Shapira, Ilana, Styr, Boaz, Braun, Gabriella, Harel, Michal, Sheinin, Anton, Geva, Nitzan, Sela, Yaniv, Saito, Takashi, Saido, Takaomi, Geiger, Tamar, Nir, Yuval, Ziv, Yaniv, Slutsky, Inna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789564/
https://www.ncbi.nlm.nih.gov/pubmed/35045289
http://dx.doi.org/10.1016/j.celrep.2021.110268

Ejemplares similares

Ejemplares similares