Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation

BACKGROUND: Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo‐HSCT), but the literature is limited. CASE: Two pediatric patients were diagnosed with PVB19 infectio...

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Autores principales: Rattani, Nabila, Matheny, Christina, Eckrich, Michael J., Madden, Lisa M., Quigg, Troy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789606/
https://www.ncbi.nlm.nih.gov/pubmed/33932151
http://dx.doi.org/10.1002/cnr2.1403
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author Rattani, Nabila
Matheny, Christina
Eckrich, Michael J.
Madden, Lisa M.
Quigg, Troy C.
author_facet Rattani, Nabila
Matheny, Christina
Eckrich, Michael J.
Madden, Lisa M.
Quigg, Troy C.
author_sort Rattani, Nabila
collection PubMed
description BACKGROUND: Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo‐HSCT), but the literature is limited. CASE: Two pediatric patients were diagnosed with PVB19 infection around the time of allo‐HSCT graft failure. Both cases were secondary graft failure and required second allo‐HSCT. CONCLUSION: There are many risk factors and potential confounders in determining the exact etiology of graft failure after allo‐HSCT. These two cases highlight the importance of including PVB19 in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo‐HSCT graft failure.
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spelling pubmed-87896062022-02-01 Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation Rattani, Nabila Matheny, Christina Eckrich, Michael J. Madden, Lisa M. Quigg, Troy C. Cancer Rep (Hoboken) Case Report BACKGROUND: Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo‐HSCT), but the literature is limited. CASE: Two pediatric patients were diagnosed with PVB19 infection around the time of allo‐HSCT graft failure. Both cases were secondary graft failure and required second allo‐HSCT. CONCLUSION: There are many risk factors and potential confounders in determining the exact etiology of graft failure after allo‐HSCT. These two cases highlight the importance of including PVB19 in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo‐HSCT graft failure. John Wiley and Sons Inc. 2021-05-01 /pmc/articles/PMC8789606/ /pubmed/33932151 http://dx.doi.org/10.1002/cnr2.1403 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rattani, Nabila
Matheny, Christina
Eckrich, Michael J.
Madden, Lisa M.
Quigg, Troy C.
Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
title Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
title_full Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
title_fullStr Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
title_full_unstemmed Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
title_short Parvovirus B19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
title_sort parvovirus b19‐associated graft failure after allogeneic hematopoietic stem cell transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789606/
https://www.ncbi.nlm.nih.gov/pubmed/33932151
http://dx.doi.org/10.1002/cnr2.1403
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