Cargando…
Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profil...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789637/ https://www.ncbi.nlm.nih.gov/pubmed/34309720 http://dx.doi.org/10.1007/s00381-021-05278-6 |
_version_ | 1784639815157809152 |
---|---|
author | Kresbach, Catena Bronsema, Annika Guerreiro, Helena Rutkowski, Stefan Schüller, Ulrich Winkler, Beate |
author_facet | Kresbach, Catena Bronsema, Annika Guerreiro, Helena Rutkowski, Stefan Schüller, Ulrich Winkler, Beate |
author_sort | Kresbach, Catena |
collection | PubMed |
description | Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profile suggesting a low-grade glioma-like subgroup. Despite an early relapse, intolerance of temozolomide, and change of treatment strategy to vinblastine and valproic acid (VPA), the patient is now in good clinical condition after more than 5 years since initial diagnosis. This case stresses the merit of methylation array data for clinical prognosis and treatment planning. |
format | Online Article Text |
id | pubmed-8789637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-87896372022-02-02 Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling Kresbach, Catena Bronsema, Annika Guerreiro, Helena Rutkowski, Stefan Schüller, Ulrich Winkler, Beate Childs Nerv Syst Case Report Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profile suggesting a low-grade glioma-like subgroup. Despite an early relapse, intolerance of temozolomide, and change of treatment strategy to vinblastine and valproic acid (VPA), the patient is now in good clinical condition after more than 5 years since initial diagnosis. This case stresses the merit of methylation array data for clinical prognosis and treatment planning. Springer Berlin Heidelberg 2021-07-26 2022 /pmc/articles/PMC8789637/ /pubmed/34309720 http://dx.doi.org/10.1007/s00381-021-05278-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Case Report Kresbach, Catena Bronsema, Annika Guerreiro, Helena Rutkowski, Stefan Schüller, Ulrich Winkler, Beate Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
title | Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
title_full | Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
title_fullStr | Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
title_full_unstemmed | Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
title_short | Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
title_sort | long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789637/ https://www.ncbi.nlm.nih.gov/pubmed/34309720 http://dx.doi.org/10.1007/s00381-021-05278-6 |
work_keys_str_mv | AT kresbachcatena longtermsurvivalofanadolescentglioblastomapatientundertreatmentwithvinblastineandvalproicacidillustratesimportanceofmethylationprofiling AT bronsemaannika longtermsurvivalofanadolescentglioblastomapatientundertreatmentwithvinblastineandvalproicacidillustratesimportanceofmethylationprofiling AT guerreirohelena longtermsurvivalofanadolescentglioblastomapatientundertreatmentwithvinblastineandvalproicacidillustratesimportanceofmethylationprofiling AT rutkowskistefan longtermsurvivalofanadolescentglioblastomapatientundertreatmentwithvinblastineandvalproicacidillustratesimportanceofmethylationprofiling AT schullerulrich longtermsurvivalofanadolescentglioblastomapatientundertreatmentwithvinblastineandvalproicacidillustratesimportanceofmethylationprofiling AT winklerbeate longtermsurvivalofanadolescentglioblastomapatientundertreatmentwithvinblastineandvalproicacidillustratesimportanceofmethylationprofiling |