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Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling

Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profil...

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Autores principales: Kresbach, Catena, Bronsema, Annika, Guerreiro, Helena, Rutkowski, Stefan, Schüller, Ulrich, Winkler, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789637/
https://www.ncbi.nlm.nih.gov/pubmed/34309720
http://dx.doi.org/10.1007/s00381-021-05278-6
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author Kresbach, Catena
Bronsema, Annika
Guerreiro, Helena
Rutkowski, Stefan
Schüller, Ulrich
Winkler, Beate
author_facet Kresbach, Catena
Bronsema, Annika
Guerreiro, Helena
Rutkowski, Stefan
Schüller, Ulrich
Winkler, Beate
author_sort Kresbach, Catena
collection PubMed
description Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profile suggesting a low-grade glioma-like subgroup. Despite an early relapse, intolerance of temozolomide, and change of treatment strategy to vinblastine and valproic acid (VPA), the patient is now in good clinical condition after more than 5 years since initial diagnosis. This case stresses the merit of methylation array data for clinical prognosis and treatment planning.
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spelling pubmed-87896372022-02-02 Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling Kresbach, Catena Bronsema, Annika Guerreiro, Helena Rutkowski, Stefan Schüller, Ulrich Winkler, Beate Childs Nerv Syst Case Report Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as a base for patient-specific treatment strategies. Here, we report on an adolescent patient with a histologically bona fide GBM that shows a molecular methylation profile suggesting a low-grade glioma-like subgroup. Despite an early relapse, intolerance of temozolomide, and change of treatment strategy to vinblastine and valproic acid (VPA), the patient is now in good clinical condition after more than 5 years since initial diagnosis. This case stresses the merit of methylation array data for clinical prognosis and treatment planning. Springer Berlin Heidelberg 2021-07-26 2022 /pmc/articles/PMC8789637/ /pubmed/34309720 http://dx.doi.org/10.1007/s00381-021-05278-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Kresbach, Catena
Bronsema, Annika
Guerreiro, Helena
Rutkowski, Stefan
Schüller, Ulrich
Winkler, Beate
Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
title Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
title_full Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
title_fullStr Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
title_full_unstemmed Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
title_short Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
title_sort long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789637/
https://www.ncbi.nlm.nih.gov/pubmed/34309720
http://dx.doi.org/10.1007/s00381-021-05278-6
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